H-β-homo-Leu-Asp-NHCH2CH2C6H5

Base Information

• Chemical Name: H-β-homo-Leu-Asp-NHCH2CH2C6H5
• CAS No.: 118247-99-7
• Molecular Formula: C₁₉H₂₉N₃O₄
• Molecular Weight: 363.457
• Mol file: 118247-99-7.mol

Synonyms:H-β-homo-Leu-Asp-NHCH2CH2C6H5

Chemical Property of H-β-homo-Leu-Asp-NHCH2CH2C6H5

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of H-β-homo-Leu-Asp-NHCH2CH2C6H5

There total 5 articles about H-β-homo-Leu-Asp-NHCH2CH2C6H5 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Benzyloxycarbonyl)-β-homo-L-leucyl-β-benzyl-L-aspartic acid 2-phenylethylamide (118247-70-4) → H-β-homo-Leu-Asp-NHCH2CH2C6H5 (118247-99-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid; for 5h; under 760 Torr; Ambient temperature;

DOI:10.1021/jm00123a003

Reference yield:

Z-Leu-OH (2018-66-8) → H-β-homo-Leu-Asp-NHCH2CH2C6H5 (118247-99-7)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) DME, -20 deg C, 5 min, 2.) DME, ether, 0 deg C, 20 min

2: silver benzoate, triethylamine / 30 h / Ambient temperature

3: 2 N NaOH / methanol / 0.5 h / 30 °C

4: (benzotriazolyloxy)tris(dimethylamino)phosphonium hexafluorophosphate, N-methylmorpholine / dimethylformamide / 1 h / Ambient temperature

5: hydrogen / 10 percent Pd/C / acetic acid / 5 h / 760 Torr / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; hydrogen; silver benzoate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; isobutyl chloroformate; palladium on activated charcoal; In methanol; acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jm00123a003

Reference yield:

(3-diazo-1-(S)-(2-methylpropyl)-2-oxopropyl)carbamic acid benzyl ester (102123-81-9) → H-β-homo-Leu-Asp-NHCH2CH2C6H5 (118247-99-7)

Guidance literature:

Multi-step reaction with 4 steps

1: silver benzoate, triethylamine / 30 h / Ambient temperature

2: 2 N NaOH / methanol / 0.5 h / 30 °C

3: (benzotriazolyloxy)tris(dimethylamino)phosphonium hexafluorophosphate, N-methylmorpholine / dimethylformamide / 1 h / Ambient temperature

4: hydrogen / 10 percent Pd/C / acetic acid / 5 h / 760 Torr / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; hydrogen; silver benzoate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; palladium on activated charcoal; In methanol; acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jm00123a003

upstream raw materials:

(Benzyloxycarbonyl)-β-homo-L-leucyl-β-benzyl-L-aspartic acid 2-phenylethylamide

Z-Leu-OH

(3-diazo-1-(S)-(2-methylpropyl)-2-oxopropyl)carbamic acid benzyl ester

N-Benzyloxycarbonyl-L-Homoleucine