(Benzyloxycarbonyl)-β-homo-L-leucyl-β-benzyl-L-aspartic acid 2-phenylethylamide

Base Information

• Chemical Name: (Benzyloxycarbonyl)-β-homo-L-leucyl-β-benzyl-L-aspartic acid 2-phenylethylamide
• CAS No.: 118247-70-4
• Molecular Formula: C₃₄H₄₁N₃O₆
• Molecular Weight: 587.716
• Mol file: 118247-70-4.mol

Synonyms:(Benzyloxycarbonyl)-β-homo-L-leucyl-β-benzyl-L-aspartic acid 2-phenylethylamide

Chemical Property of (Benzyloxycarbonyl)-β-homo-L-leucyl-β-benzyl-L-aspartic acid 2-phenylethylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Benzyloxycarbonyl)-β-homo-L-leucyl-β-benzyl-L-aspartic acid 2-phenylethylamide

There total 4 articles about (Benzyloxycarbonyl)-β-homo-L-leucyl-β-benzyl-L-aspartic acid 2-phenylethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Z-Leu-OH (2018-66-8) → (Benzyloxycarbonyl)-β-homo-L-leucyl-β-benzyl-L-aspartic acid 2-phenylethylamide (118247-70-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) DME, -20 deg C, 5 min, 2.) DME, ether, 0 deg C, 20 min

2: silver benzoate, triethylamine / 30 h / Ambient temperature

3: 2 N NaOH / methanol / 0.5 h / 30 °C

4: (benzotriazolyloxy)tris(dimethylamino)phosphonium hexafluorophosphate, N-methylmorpholine / dimethylformamide / 1 h / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; silver benzoate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; isobutyl chloroformate; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00123a003

Reference yield:

(3-diazo-1-(S)-(2-methylpropyl)-2-oxopropyl)carbamic acid benzyl ester (102123-81-9) → (Benzyloxycarbonyl)-β-homo-L-leucyl-β-benzyl-L-aspartic acid 2-phenylethylamide (118247-70-4)

Guidance literature:

Multi-step reaction with 3 steps

1: silver benzoate, triethylamine / 30 h / Ambient temperature

2: 2 N NaOH / methanol / 0.5 h / 30 °C

3: (benzotriazolyloxy)tris(dimethylamino)phosphonium hexafluorophosphate, N-methylmorpholine / dimethylformamide / 1 h / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; silver benzoate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00123a003

Reference yield:

methyl (S)-3-(benzyloxycarbonylamino)-5-methylhexanoate (96386-94-6) → (Benzyloxycarbonyl)-β-homo-L-leucyl-β-benzyl-L-aspartic acid 2-phenylethylamide (118247-70-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 2 N NaOH / methanol / 0.5 h / 30 °C

2: (benzotriazolyloxy)tris(dimethylamino)phosphonium hexafluorophosphate, N-methylmorpholine / dimethylformamide / 1 h / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00123a003

upstream raw materials:

H-Asp(OBzl)-NHCH₂CH₂C₆H₅*TFA

N-Benzyloxycarbonyl-L-Homoleucine

Z-Leu-OH

(3-diazo-1-(S)-(2-methylpropyl)-2-oxopropyl)carbamic acid benzyl ester

Downstream raw materials:

H-β-homo-Leu-Asp-NHCH2CH2C6H5

(tert-Butoxycarbonyl)-L-tryptophyl-β-homo-L-leucyl-L-aspartic acid 2-phenylethylamide