(Benzyloxycarbonyl)-β-homo-L-leucyl-β-benzyl-L-aspartic acid 2-phenylethylamide

Base Information

Chemical Name:(Benzyloxycarbonyl)-β-homo-L-leucyl-β-benzyl-L-aspartic acid 2-phenylethylamide
CAS No.:118247-70-4
Molecular Formula:C₃₄H₄₁N₃O₆
Molecular Weight:587.716
Hs Code.:

Synonyms:(Benzyloxycarbonyl)-β-homo-L-leucyl-β-benzyl-L-aspartic acid 2-phenylethylamide

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Chemical Property of (Benzyloxycarbonyl)-β-homo-L-leucyl-β-benzyl-L-aspartic acid 2-phenylethylamide

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Technology Process of (Benzyloxycarbonyl)-β-homo-L-leucyl-β-benzyl-L-aspartic acid 2-phenylethylamide

There total 4 articles about (Benzyloxycarbonyl)-β-homo-L-leucyl-β-benzyl-L-aspartic acid 2-phenylethylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2018-66-8
Z-Leu-OH

: 118247-70-4
(Benzyloxycarbonyl)-β-homo-L-leucyl-β-benzyl-L-aspartic acid 2-phenylethylamide

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) isobutyl chloroformate, N-methylmorpholine / 1.) DME, -20 deg C, 5 min, 2.) DME, ether, 0 deg C, 20 min

2: silver benzoate, triethylamine / 30 h / Ambient temperature

3: 2 N NaOH / methanol / 0.5 h / 30 °C

4: (benzotriazolyloxy)tris(dimethylamino)phosphonium hexafluorophosphate, N-methylmorpholine / dimethylformamide / 1 h / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; silver benzoate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; isobutyl chloroformate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00123a003

Reference yield:

: 102123-81-9
(3-diazo-1-(S)-(2-methylpropyl)-2-oxopropyl)carbamic acid benzyl ester

: 118247-70-4
(Benzyloxycarbonyl)-β-homo-L-leucyl-β-benzyl-L-aspartic acid 2-phenylethylamide

Guidance literature:: Multi-step reaction with 3 steps

1: silver benzoate, triethylamine / 30 h / Ambient temperature

2: 2 N NaOH / methanol / 0.5 h / 30 °C

3: (benzotriazolyloxy)tris(dimethylamino)phosphonium hexafluorophosphate, N-methylmorpholine / dimethylformamide / 1 h / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; silver benzoate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00123a003

Reference yield:

: 96386-94-6
methyl (S)-3-(benzyloxycarbonylamino)-5-methylhexanoate

: 118247-70-4
(Benzyloxycarbonyl)-β-homo-L-leucyl-β-benzyl-L-aspartic acid 2-phenylethylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 2 N NaOH / methanol / 0.5 h / 30 °C

2: (benzotriazolyloxy)tris(dimethylamino)phosphonium hexafluorophosphate, N-methylmorpholine / dimethylformamide / 1 h / Ambient temperature

With 4-methyl-morpholine; sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00123a003