(1R)-1-(2,4,6-triisopropylphenyl)ethyl-1H-1-imidazolecarboxylate

Base Information

• Chemical Name: (1R)-1-(2,4,6-triisopropylphenyl)ethyl-1H-1-imidazolecarboxylate
• CAS No.: 245674-29-7
• Molecular Formula: C₂₁H₃₀N₂O₂
• Molecular Weight: 342.481
• Mol file: 245674-29-7.mol

Synonyms:(1R)-1-(2,4,6-triisopropylphenyl)ethyl-1H-1-imidazolecarboxylate

Chemical Property of (1R)-1-(2,4,6-triisopropylphenyl)ethyl-1H-1-imidazolecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R)-1-(2,4,6-triisopropylphenyl)ethyl-1H-1-imidazolecarboxylate

There total 1 articles about (1R)-1-(2,4,6-triisopropylphenyl)ethyl-1H-1-imidazolecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1,1'-carbonyldiimidazole (530-62-1) + (R)-(+)-1-(2,4,6-triisopropylphenyl)ethanol (181531-14-6) → (1R)-1-(2,4,6-triisopropylphenyl)ethyl-1H-1-imidazolecarboxylate (245674-29-7)

Guidance literature:

In dichloromethane; at 20 ℃;

DOI:10.1016/S0040-4039(99)01638-X

Reference yield: 55.0%

2-pyrrolidinon (616-45-5) + (1R)-1-(2,4,6-triisopropylphenyl)ethyl-1H-1-imidazolecarboxylate (245674-29-7) → (1R)-1-(2,4,6-triisopropylphenyl)ethyl-2-oxo-1-pyrrolidinecarboxylate (245674-32-2)

Guidance literature:

at 85 ℃; for 56h;

DOI:10.1016/S0040-4039(99)01638-X

Reference yield:

(1R)-1-(2,4,6-triisopropylphenyl)ethyl-1H-1-imidazolecarboxylate (245674-29-7) → (1R)-1-(2,4,6-triisopropylphenyl)ethyl-2,3-dihydro-1H-1-pyrrolecarboxylate (245674-46-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 55 percent / 52 h / 85 °C

2.1: 93 percent / DIBAL-H / tetrahydrofuran; hexane / 1 h / -78 °C

3.1: (CF₃CO)2O; 2,6-lutidine / toluene / 7 h / 0 °C

3.2: 98 percent / 0.33 h / Heating

With 2,6-dimethylpyridine; diisobutylaluminium hydride; trifluoroacetic anhydride; In tetrahydrofuran; hexane; toluene; 1.1: Substitution / 2.1: Reduction / 3.1: Acylation / 3.2: Elimination;

DOI:10.1021/jo9903297

upstream raw materials:

1,1'-carbonyldiimidazole

(R)-(+)-1-(2,4,6-triisopropylphenyl)ethanol

Downstream raw materials:

(1R)-1-(2,4,6-triisopropylphenyl)ethyl-2-oxo-1-pyrrolidinecarboxylate

(1R)-1-(2,4,6-triisopropylphenyl)ethyl-2,3-dihydro-1H-1-pyrrolecarboxylate

(1R,2RS)-1-(2,4,6-triisopropylphenyl)ethyl-2-hydroxy-1-pyrrolidinecarboxylate