(S)-1-(2,4,6-Triisopropylphenyl)ethanol

Base Information

• Chemical Name: (S)-1-(2,4,6-Triisopropylphenyl)ethanol
• CAS No.: 102225-88-7
• Molecular Formula: C17H28 O
• Molecular Weight: 248.409
• Hs Code.: 2906290090
• DSSTox Substance ID: DTXSID40447339
• Nikkaji Number: J767.564J
• Wikidata: Q82266200
• Mol file: 102225-88-7.mol

Synonyms:102225-88-7;(S)-1-(2,4,6-Triisopropylphenyl)ethanol;(S)-(-)-STERICOL;(S)-(-)-1-(2,4,6-Triisopropylphenyl)ethanol;(1S)-1-[2,4,6-tri(propan-2-yl)phenyl]ethanol;(1S)-1-[2,4,6-Tri(propan-2-yl)phenyl]ethan-1-ol;Benzenemethanol, alpha-methyl-2,4,6-tris(1-methylethyl)-, (alphaS)-;FS-0002;(S)-(?)-Stericol;DTXSID40447339;CEA22588;MFCD09836213;AKOS016340203;CS-0439909;(S)-1-(2,4,6-triisopropylphenyl)ethan-1-ol;(S)-(?)-1-(2,4,6-Triisopropylphenyl)ethanol;(S)-(^')-1-(2,4,6-Triisopropylphenyl)ethanol;J-502334;(1S)-1-[2,4,6-tris(propan-2-yl)phenyl]ethan-1-ol;(S)-(-)-1-(2,4,6-Triisopropylphenyl)ethanol, >=98.5% (HPLC)

Chemical Property of (S)-1-(2,4,6-Triisopropylphenyl)ethanol

Chemical Property:

• Melting Point: 82-86 °C
• PSA: 20.23000
• LogP: 5.11010
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 248.214015512
• Heavy Atom Count: 18
• Complexity: 226

Purity/Quality:

97% ^*data from raw suppliers

(S)-(-)-Stericol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C1=CC(=C(C(=C1)C(C)C)C(C)O)C(C)C
• Isomeric SMILES: C[C@@H](C1=C(C=C(C=C1C(C)C)C(C)C)C(C)C)O

Technology Process of (S)-1-(2,4,6-Triisopropylphenyl)ethanol

There total 16 articles about (S)-1-(2,4,6-Triisopropylphenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

1-(2,4,6-triisopropylphenyl)ethanone (2234-14-2) → (+/-)-1-(2,4,6-triisopropylphenyl)ethanol (102225-88-7,24226-23-1)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 20 ℃; for 3h;

DOI:10.1021/ja0528937

Reference yield:

1'-(2'',4'',6''-triisopropylphenyl)ethyl acetoxyacetate (1400563-23-6) → (-)-(S)-1-(2,4,6-triisopropylphenyl)ethanol (102225-88-7) + (R)-(+)-1-(2,4,6-triisopropylphenyl)ethanol (181531-14-6)

Guidance literature:

With methanol; potassium carbonate; Reflux;

DOI:10.1016/j.molcatb.2012.05.006

Reference yield:

(+/-)-1-(2,4,6-triisopropylphenyl)ethanol (102225-88-7,24226-23-1) → (-)-(S)-1-(2,4,6-triisopropylphenyl)ethanol (102225-88-7) + (R)-(+)-1-(2,4,6-triisopropylphenyl)ethanol (181531-14-6)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; dmap / 4 h / 20 °C

2: methanol; potassium carbonate / Reflux

With pyridine; methanol; dmap; potassium carbonate;

DOI:10.1016/j.molcatb.2012.05.006

upstream raw materials:

1-(2,4,6-triisopropylphenyl)ethanone

1,3,5-triisopropyl benzene

Phthalic acid mono-[(S)-1-(2,4,6-triisopropyl-phenyl)-ethyl] ester

(+/-)-1-(2,4,6-triisopropylphenyl)ethanol

Downstream raw materials:

Phthalic acid mono-[1-(2,4,6-triisopropyl-phenyl)-ethyl] ester

2-(1-azido-ethyl)-1,3,5-triisopropyl-benzene

(S)-1-(2,4,6-triisopropylphenyl)ethylamine

(R)-1-(2,4,6-triisopropylphenyl)ethylamine