(R)-2-[2-(2-bromo-5-fluoropyridin-4-yl)-2-(2-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionic acid ethyl ester

Base Information

Chemical Name:(R)-2-[2-(2-bromo-5-fluoropyridin-4-yl)-2-(2-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionic acid ethyl ester
CAS No.:1387560-91-9
Molecular Formula:C₂₀H₂₀BrF₄N₃O₇S
Molecular Weight:602.358
Hs Code.:

Synonyms:(R)-2-[2-(2-bromo-5-fluoropyridin-4-yl)-2-(2-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionic acid ethyl ester

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Chemical Property of (R)-2-[2-(2-bromo-5-fluoropyridin-4-yl)-2-(2-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionic acid ethyl ester

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Technology Process of (R)-2-[2-(2-bromo-5-fluoropyridin-4-yl)-2-(2-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionic acid ethyl ester

There total 7 articles about (R)-2-[2-(2-bromo-5-fluoropyridin-4-yl)-2-(2-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1387560-89-5
2-bromo-5-fluoro-4-[2-methyl-1-(2-nitrobenzenesulfonyl)aziridin-2-yl]pyridine

: 1262860-78-5
(R)-3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid ethyl ester

: 1387560-91-9
(R)-2-[2-(2-bromo-5-fluoropyridin-4-yl)-2-(2-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionic acid ethyl ester

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.1c01300

Reference yield:

: 1387560-90-8
2-bromo-5-fluoro-4-(2-methylaziridin-2-yl)pyridine

: 1387560-91-9
(R)-2-[2-(2-bromo-5-fluoropyridin-4-yl)-2-(2-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methyl-morpholine; aluminum oxide / water; tetrahydrofuran / 1.5 h / 20 °C

2: N,N-dimethyl-formamide / 3 h / 20 °C

With 4-methyl-morpholine; aluminum oxide; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 41404-58-4
2-bromo-5-fluoropyridine

: 1387560-91-9
(R)-2-[2-(2-bromo-5-fluoropyridin-4-yl)-2-(2-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: lithium diisopropyl amide / tetrahydrofuran; acetone / 2 h / -78 °C / Inert atmosphere

2: triethylamine; Methanesulfonic anhydride / dichloromethane / 40 h / 20 °C

3: osmium(VIII) oxide / water; acetone / 17 h / 20 °C

4: triethylamine / dichloromethane / 0.67 h / 0 °C

5: sodium azide; ammonium chloride / ethanol / 20 h / 80 °C

6: triethylamine / dichloromethane / 2 h / 0 - 20 °C

7: triphenylphosphine; citric acid / water; tert-butyl methyl ether; tetrahydrofuran / 0.5 h / 20 °C

8: 4-methyl-morpholine; aluminum oxide / water; tetrahydrofuran / 1.5 h / 20 °C

9: N,N-dimethyl-formamide / 3 h / 20 °C

With 4-methyl-morpholine; aluminum oxide; osmium(VIII) oxide; sodium azide; ammonium chloride; triethylamine; triphenylphosphine; citric acid; lithium diisopropyl amide; Methanesulfonic anhydride; In tetrahydrofuran; ethanol; dichloromethane; tert-butyl methyl ether; water; N,N-dimethyl-formamide; acetone;