(R)-2-[2-(2-bromo-5-fluoropyridin-4-yl)-2-(2-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionamide

Base Information

Chemical Name:(R)-2-[2-(2-bromo-5-fluoropyridin-4-yl)-2-(2-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionamide
CAS No.:1387560-92-0
Molecular Formula:C₁₈H₁₇BrF₄N₄O₆S
Molecular Weight:573.32
Hs Code.:

Synonyms:(R)-2-[2-(2-bromo-5-fluoropyridin-4-yl)-2-(2-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionamide

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Chemical Property of (R)-2-[2-(2-bromo-5-fluoropyridin-4-yl)-2-(2-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionamide

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Technology Process of (R)-2-[2-(2-bromo-5-fluoropyridin-4-yl)-2-(2-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionamide

There total 8 articles about (R)-2-[2-(2-bromo-5-fluoropyridin-4-yl)-2-(2-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1387560-91-9
(R)-2-[2-(2-bromo-5-fluoropyridin-4-yl)-2-(2-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionic acid ethyl ester

: 1387560-92-0
(R)-2-[2-(2-bromo-5-fluoropyridin-4-yl)-2-(2-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionamide

Guidance literature:: With ammonia; In methanol; at 55 ℃; for 44h; Inert atmosphere; Sealed tube;
DOI:10.1021/acs.jmedchem.1c01300

Reference yield:

: 1387560-89-5
2-bromo-5-fluoro-4-[2-methyl-1-(2-nitrobenzenesulfonyl)aziridin-2-yl]pyridine

: 1387560-92-0
(R)-2-[2-(2-bromo-5-fluoropyridin-4-yl)-2-(2-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionamide

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 3 h / 20 °C

2: ammonia / methanol / 44 h / 55 °C / Sealed vial

With ammonia; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1387560-90-8
2-bromo-5-fluoro-4-(2-methylaziridin-2-yl)pyridine

: 1387560-92-0
(R)-2-[2-(2-bromo-5-fluoropyridin-4-yl)-2-(2-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionamide

Guidance literature:: Multi-step reaction with 3 steps

1: 4-methyl-morpholine; aluminum oxide / water; tetrahydrofuran / 1.5 h / 20 °C

2: N,N-dimethyl-formamide / 3 h / 20 °C

3: ammonia / methanol / 44 h / 55 °C / Sealed vial

With 4-methyl-morpholine; aluminum oxide; ammonia; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;