N-[1-(2-bromo-5-fluoropyridin-4-yl)-2-((R)-1-cyano-2,2,2-trifluoro-1-methylethoxy)-1-methylethyl]-2-nitrobenzenesulfonamide

Base Information

Chemical Name:N-[1-(2-bromo-5-fluoropyridin-4-yl)-2-((R)-1-cyano-2,2,2-trifluoro-1-methylethoxy)-1-methylethyl]-2-nitrobenzenesulfonamide
CAS No.:1387560-93-1
Molecular Formula:C₁₈H₁₅BrF₄N₄O₅S
Molecular Weight:555.305
Hs Code.:

Synonyms:N-[1-(2-bromo-5-fluoropyridin-4-yl)-2-((R)-1-cyano-2,2,2-trifluoro-1-methylethoxy)-1-methylethyl]-2-nitrobenzenesulfonamide

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Chemical Property of N-[1-(2-bromo-5-fluoropyridin-4-yl)-2-((R)-1-cyano-2,2,2-trifluoro-1-methylethoxy)-1-methylethyl]-2-nitrobenzenesulfonamide

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Technology Process of N-[1-(2-bromo-5-fluoropyridin-4-yl)-2-((R)-1-cyano-2,2,2-trifluoro-1-methylethoxy)-1-methylethyl]-2-nitrobenzenesulfonamide

There total 8 articles about N-[1-(2-bromo-5-fluoropyridin-4-yl)-2-((R)-1-cyano-2,2,2-trifluoro-1-methylethoxy)-1-methylethyl]-2-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1387560-92-0
(R)-2-[2-(2-bromo-5-fluoropyridin-4-yl)-2-(2-nitrobenzenesulfonylamino)propoxy]-3,3,3-trifluoro-2-methylpropionamide

: 1387560-93-1
N-[1-(2-bromo-5-fluoropyridin-4-yl)-2-((R)-1-cyano-2,2,2-trifluoro-1-methylethoxy)-1-methylethyl]-2-nitrobenzenesulfonamide

Guidance literature:: With triethylamine; trifluoroacetic anhydride; In dichloromethane; at 0 - 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.1c01300

Reference yield:

: 1387560-89-5
2-bromo-5-fluoro-4-[2-methyl-1-(2-nitrobenzenesulfonyl)aziridin-2-yl]pyridine

: 1387560-93-1
N-[1-(2-bromo-5-fluoropyridin-4-yl)-2-((R)-1-cyano-2,2,2-trifluoro-1-methylethoxy)-1-methylethyl]-2-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 3 h / 20 °C

2: ammonia / methanol / 44 h / 55 °C / Sealed vial

3: triethylamine; trifluoroacetic anhydride / dichloromethane / 1.5 h / 0 - 20 °C

With ammonia; triethylamine; trifluoroacetic anhydride; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 41404-58-4
2-bromo-5-fluoropyridine

: 1387560-93-1
N-[1-(2-bromo-5-fluoropyridin-4-yl)-2-((R)-1-cyano-2,2,2-trifluoro-1-methylethoxy)-1-methylethyl]-2-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 11 steps

1: lithium diisopropyl amide / tetrahydrofuran; acetone / 2 h / -78 °C / Inert atmosphere

2: triethylamine; Methanesulfonic anhydride / dichloromethane / 40 h / 20 °C

3: osmium(VIII) oxide / water; acetone / 17 h / 20 °C

4: triethylamine / dichloromethane / 0.67 h / 0 °C

5: sodium azide; ammonium chloride / ethanol / 20 h / 80 °C

6: triethylamine / dichloromethane / 2 h / 0 - 20 °C

7: triphenylphosphine; citric acid / water; tert-butyl methyl ether; tetrahydrofuran / 0.5 h / 20 °C

8: 4-methyl-morpholine; aluminum oxide / water; tetrahydrofuran / 1.5 h / 20 °C

9: N,N-dimethyl-formamide / 3 h / 20 °C

10: ammonia / methanol / 44 h / 55 °C / Sealed vial

11: triethylamine; trifluoroacetic anhydride / dichloromethane / 1.5 h / 0 - 20 °C

With 4-methyl-morpholine; aluminum oxide; osmium(VIII) oxide; sodium azide; ammonia; ammonium chloride; triethylamine; triphenylphosphine; trifluoroacetic anhydride; citric acid; lithium diisopropyl amide; Methanesulfonic anhydride; In tetrahydrofuran; methanol; ethanol; dichloromethane; tert-butyl methyl ether; water; N,N-dimethyl-formamide; acetone;