4-{2-chloro-6-[1-(phenylsulfonyl)cyclopropyl]pyrimidin-4-yl}morpholine

Base Information

Chemical Name:4-{2-chloro-6-[1-(phenylsulfonyl)cyclopropyl]pyrimidin-4-yl}morpholine
CAS No.:1101819-82-2
Molecular Formula:C₁₇H₁₈ClN₃O₃S
Molecular Weight:379.867
Hs Code.:

Synonyms:4-{2-chloro-6-[1-(phenylsulfonyl)cyclopropyl]pyrimidin-4-yl}morpholine

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Chemical Property of 4-{2-chloro-6-[1-(phenylsulfonyl)cyclopropyl]pyrimidin-4-yl}morpholine

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Technology Process of 4-{2-chloro-6-[1-(phenylsulfonyl)cyclopropyl]pyrimidin-4-yl}morpholine

There total 6 articles about 4-{2-chloro-6-[1-(phenylsulfonyl)cyclopropyl]pyrimidin-4-yl}morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1009627-47-7
4-{2-chloro-6-[(phenylsulfonyl)methyl]pyrimidin-4-yl}morpholine

: 106-93-4
ethylene dibromide

: 1101819-82-2
4-{2-chloro-6-[1-(phenylsulfonyl)cyclopropyl]pyrimidin-4-yl}morpholine

Guidance literature:: With tetrabutylammomium bromide; sodium hydroxide; In dichloromethane; water; toluene; at 60 ℃; for 18h; Inert atmosphere;
DOI:10.1021/jm301859s

Reference yield:

: 6299-85-0
2,6-dichloropyrimidine-4-carboxylic acid methyl ester

: 1101819-82-2
4-{2-chloro-6-[1-(phenylsulfonyl)cyclopropyl]pyrimidin-4-yl}morpholine

Guidance literature:: Multi-step reaction with 6 steps

1: triethylamine / dichloromethane / 4 h / -5 - 0 °C / Inert atmosphere

2: lithium borohydride / tetrahydrofuran / 3.5 h / -5 - 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

4: sodium iodide / acetone / 2 h / 20 °C / Inert atmosphere

5: acetonitrile / 3 h / 80 °C / Inert atmosphere

6: sodium hydroxide; tetrabutylammomium bromide / water; dichloromethane; toluene / 18 h / 60 °C / Inert atmosphere

With lithium borohydride; tetrabutylammomium bromide; triethylamine; N-ethyl-N,N-diisopropylamine; sodium iodide; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; acetone; toluene; acetonitrile;
DOI:10.1021/jm301859s

Reference yield:

: 107973-01-3
Methyl Ester of 6-Morpholino-2-chloropyrimidine-4-carboxylic acid

: 1101819-82-2
4-{2-chloro-6-[1-(phenylsulfonyl)cyclopropyl]pyrimidin-4-yl}morpholine

Guidance literature:: Multi-step reaction with 5 steps

1: lithium borohydride / tetrahydrofuran / 3.5 h / -5 - 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere

3: sodium iodide / acetone / 2 h / 20 °C / Inert atmosphere

4: acetonitrile / 3 h / 80 °C / Inert atmosphere

5: sodium hydroxide; tetrabutylammomium bromide / water; dichloromethane; toluene / 18 h / 60 °C / Inert atmosphere

With lithium borohydride; tetrabutylammomium bromide; N-ethyl-N,N-diisopropylamine; sodium iodide; sodium hydroxide; In tetrahydrofuran; dichloromethane; water; acetone; toluene; acetonitrile;
DOI:10.1021/jm301859s