1-((4-amino-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutanol

Base Information

Chemical Name:1-((4-amino-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutanol
CAS No.:1099665-13-0
Molecular Formula:C₁₂H₁₅F₂NO₃
Molecular Weight:259.253
Hs Code.:

Synonyms:1-((4-amino-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutanol

Suppliers and Price of 1-((4-amino-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-((4-amino-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutanol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-((4-amino-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutanol

There total 6 articles about 1-((4-amino-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1197420-25-9
3,3-difluoro-1-((2-methoxy-4-nitrophenoxy)methyl)cyclobutanol

: 1099665-13-0
1-((4-amino-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutanol

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; for 1.5h; under 2585.81 Torr;

Reference yield:

: 1197420-23-7
1-(3,3-difluorocyclobutyl)-N,N-dimethylmethanamine oxide

: 1099665-13-0
1-((4-amino-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutanol

Guidance literature:: Multi-step reaction with 4 steps

1: water / 165 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Cooling with ice

3: sodium dihydrogen phosphate monohydrate / water; acetonitrile / 3.5 h / 130 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 1.5 h / 2585.81 Torr

With sodium dihydrogen phosphate monohydrate; palladium 10% on activated carbon; hydrogen; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane; water; acetonitrile; 1: |Cope Elimination;
DOI:10.1021/acs.jmedchem.6b00676

Reference yield:

: 107496-54-8
3,3-difluorocyclobutanecarboxylic acid

: 1099665-13-0
1-((4-amino-2-methoxyphenoxy)methyl)-3,3-difluorocyclobutanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 - 20 °C

1.2: 0.5 h / 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 18 h / 0 - 20 °C

3.1: dihydrogen peroxide / methanol; water / 23 h / 5 - 22 °C

4.1: water / 165 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 °C / Cooling with ice

6.1: sodium dihydrogen phosphate monohydrate / water; acetonitrile / 3.5 h / 130 °C

7.1: palladium 10% on activated carbon; hydrogen / methanol / 1.5 h / 2585.81 Torr

With lithium aluminium tetrahydride; sodium dihydrogen phosphate monohydrate; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; N,N-dimethyl-formamide; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile; 4.1: |Cope Elimination;
DOI:10.1021/acs.jmedchem.6b00676