2-[6-(4-methyl-piperazin-1-ylmethyl)-benzoimidazol-1-yl]-4-(2-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide

Base Information

Chemical Name:2-[6-(4-methyl-piperazin-1-ylmethyl)-benzoimidazol-1-yl]-4-(2-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide
CAS No.:1232233-87-2
Molecular Formula:C₂₄H₂₃F₃N₆OS
Molecular Weight:500.547
Hs Code.:

Synonyms:2-[6-(4-methyl-piperazin-1-ylmethyl)-benzoimidazol-1-yl]-4-(2-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide

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Chemical Property of 2-[6-(4-methyl-piperazin-1-ylmethyl)-benzoimidazol-1-yl]-4-(2-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide

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Technology Process of 2-[6-(4-methyl-piperazin-1-ylmethyl)-benzoimidazol-1-yl]-4-(2-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide

There total 12 articles about 2-[6-(4-methyl-piperazin-1-ylmethyl)-benzoimidazol-1-yl]-4-(2-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64-18-6
formic acid

: 1232234-65-9
2-[5-(4-methyl-piperazin-1-ylmethyl)-2-nitro-phenylamino]-4-(2-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide

: 1232233-87-2
2-[6-(4-methyl-piperazin-1-ylmethyl)-benzoimidazol-1-yl]-4-(2-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide

Guidance literature:: formic acid; 2-[5-(4-methyl-piperazin-1-ylmethyl)-2-nitro-phenylamino]-4-(2-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide; With hydrogen; palladium 10% on activated carbon; for 18h;

With sodium hydrogencarbonate; In dichloromethane;

Reference yield:

: 1232234-37-5
4-dimethoxymethyl-2-fluoro-1-nitro-benzene

: 1232233-87-2
2-[6-(4-methyl-piperazin-1-ylmethyl)-benzoimidazol-1-yl]-4-(2-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

2: hydrogenchloride; water / acetonitrile / 3 h / 60 °C

3: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

4: hydrogen / palladium 10% on activated carbon / 18 h

With hydrogenchloride; water; hydrogen; sodium tris(acetoxy)borohydride; caesium carbonate; palladium 10% on activated carbon; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1232234-22-8
3-oxo-3-(2-trifluoromethyl-phenyl)-propionamide

: 1232233-87-2
2-[6-(4-methyl-piperazin-1-ylmethyl)-benzoimidazol-1-yl]-4-(2-trifluoromethyl-phenyl)-thiazole-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 7 steps

1: copper(ll) bromide / ethyl acetate / Reflux

2: ethanol / 20 °C

3: ethanol / 60 °C

4: caesium carbonate / N,N-dimethyl-formamide / 3 h / 60 °C

5: hydrogenchloride; water / acetonitrile / 3 h / 60 °C

6: sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

7: hydrogen / palladium 10% on activated carbon / 18 h

With hydrogenchloride; water; hydrogen; sodium tris(acetoxy)borohydride; caesium carbonate; copper(ll) bromide; palladium 10% on activated carbon; In ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;