1245078-62-9

Basic information

• Product Name: 3-(2,5-difluorophenyl)-4-nitrobutyric acid methyl ester
• Synonyms: 3-(2,5-difluorophenyl)-4-nitrobutyric acid methyl ester
• CAS NO: 1245078-62-9
• Molecular Weight: 259.209
• Mol File: 1245078-62-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 3-(2,5-difluorophenyl)-4-nitrobutyric acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2,5-difluorophenyl)-4-nitrobutyric acid methyl ester(1245078-62-9)
• EPA Substance Registry System: 3-(2,5-difluorophenyl)-4-nitrobutyric acid methyl ester(1245078-62-9)

Safety Data

• Hazardous Substances Data: 1245078-62-9(Hazardous Substances Data)

Upstream product

• 75-52-5 nitromethane 
• 112898-33-6 3-(2,5-difluorophenyl)acrylic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 1007862-01-2 methyl (2E)-3-(2,5-difluorophenyl)-2-propenoate 

Downstream Products

• 1351338-64-1 4-(5-{2-[(3R,4R)-3-amino-4-(2,5-difluorophenyl)piperidin-1-yl]pyrimidin-5-yloxymethyl}-[1,2,4]oxadiazol-3-yl)piperidine-1-carboxylic acid isopropyl ester hydrochloride 
• 1351341-71-3 4-(5-{2-[(3R,4R)-3-tert-butoxycarbonylamino-4-(2,5-difluorophenyl)piperidin-1-yl]pyrimidin-5-yloxymethyl}-[1,2,4]oxadiazol-3-yl)piperidine-1-carboxylic acid isopropyl ester 
• 1245078-67-4 [(3R,4R)-4-(2,5-difluorophenyl)piperidin-3-yl]carbamic acid tert-butyl ester 
• 1245078-65-2 [(3R,4R)-1-benzyl-4-(2,5-difluorophenyl)piperidin-3-yl]carbamic acid tert-butyl ester 

Relevant articles and documents

CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS

Therapeutic compounds are disclosed having the general formula (I) that are useful for the treatment of metabolic disorders, including type II diabetes. The compounds have activity as agonists of GPR119. Compounds having the stereochemistry of formula (la) may also demonstrate DPP-IV inhibitory activity.

COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS

The present invention is directed to therapeutic compotmds of the following formula (I) which have activity as agonists of GPR 119 and are useful for the treatment of metabolic disorders including type II diabetes.