2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-1,4'-l',2',3',4'-tetrahydroquinoline)-6-carboxylic acid cyclobutylamide

Base Information

Chemical Name:2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-1,4'-l',2',3',4'-tetrahydroquinoline)-6-carboxylic acid cyclobutylamide
CAS No.:1353969-31-9
Molecular Formula:C₂₃H₂₅FN₂O
Molecular Weight:364.463
Hs Code.:

Synonyms:2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-1,4'-l',2',3',4'-tetrahydroquinoline)-6-carboxylic acid cyclobutylamide

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Chemical Property of 2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-1,4'-l',2',3',4'-tetrahydroquinoline)-6-carboxylic acid cyclobutylamide

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Technology Process of 2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-1,4'-l',2',3',4'-tetrahydroquinoline)-6-carboxylic acid cyclobutylamide

There total 5 articles about 2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-1,4'-l',2',3',4'-tetrahydroquinoline)-6-carboxylic acid cyclobutylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.3%

: 2516-34-9
cyclobutylamine

: 1353968-56-5
2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-1,4'-1',2',3',4'-tetrahydroquinoline)-6-carboxylic acid

: 1353969-31-9
2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-1,4'-l',2',3',4'-tetrahydroquinoline)-6-carboxylic acid cyclobutylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;

Reference yield:

: 619-45-4
4-methoxycarbonyl aniline

: 1353969-31-9
2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-1,4'-l',2',3',4'-tetrahydroquinoline)-6-carboxylic acid cyclobutylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: toluene-4-sulfonic acid / toluene / 12 h / Reflux

2.1: scandium tris(trifluoromethanesulfonate) / acetonitrile / 16 h / 80 °C / Sealed tube

3.1: sodium hydroxide; methanol / tetrahydrofuran / 6 h / 80 °C

3.2: pH 4

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With methanol; toluene-4-sulfonic acid; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; scandium tris(trifluoromethanesulfonate); In tetrahydrofuran; N,N-dimethyl-formamide; toluene; acetonitrile; 2.1: Diels-Alder Reaction;

Reference yield:

: 1353970-87-2
4-[(5-fluoro-2-methyl-benzylidene)-amino]-benzoic acid methyl ester

: 1353969-31-9
2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-1,4'-l',2',3',4'-tetrahydroquinoline)-6-carboxylic acid cyclobutylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: scandium tris(trifluoromethanesulfonate) / acetonitrile / 16 h / 80 °C / Sealed tube

2.1: sodium hydroxide; methanol / tetrahydrofuran / 6 h / 80 °C

2.2: pH 4

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With methanol; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; scandium tris(trifluoromethanesulfonate); In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 1.1: Diels-Alder Reaction;