2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-1,4'-1',2',3',4'-tetrahydroquinoline)-6-carboxylic acid

Base Information

Chemical Name:2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-1,4'-1',2',3',4'-tetrahydroquinoline)-6-carboxylic acid
CAS No.:1353968-56-5
Molecular Formula:C₁₉H₁₈FNO₂
Molecular Weight:311.356
Hs Code.:

Synonyms:2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-1,4'-1',2',3',4'-tetrahydroquinoline)-6-carboxylic acid

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Chemical Property of 2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-1,4'-1',2',3',4'-tetrahydroquinoline)-6-carboxylic acid

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Technology Process of 2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-1,4'-1',2',3',4'-tetrahydroquinoline)-6-carboxylic acid

There total 1 articles about 2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-1,4'-1',2',3',4'-tetrahydroquinoline)-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1353970-91-8
2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-l,4'-l',2',3',4'-tetrahydroquinoline)-6-carboxylic acid methyl ester

: 1353968-56-5
2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-1,4'-1',2',3',4'-tetrahydroquinoline)-6-carboxylic acid

Guidance literature:: 2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-l,4'-l',2',3',4'-tetrahydroquinoline)-6-carboxylic acid methyl ester; With methanol; sodium hydroxide; In tetrahydrofuran; at 80 ℃; for 6h;

With hydrogenchloride; In water; pH=4;

Reference yield: 31.3%

: 2516-34-9
cyclobutylamine

: 1353968-56-5
2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-1,4'-1',2',3',4'-tetrahydroquinoline)-6-carboxylic acid

: 1353969-31-9
2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-1,4'-l',2',3',4'-tetrahydroquinoline)-6-carboxylic acid cyclobutylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;

Reference yield: 30.0%

: 3144-09-0
methanesulfonamide

: 1353968-56-5
2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-1,4'-1',2',3',4'-tetrahydroquinoline)-6-carboxylic acid

: 1391608-78-8
2'-(5-Fluoro-2-methylphenyl)-N-(methylsulfonyl)-2',3'-dihydro-1'H-spiro[cyclopropane-1,4'-quinoline]-6'-carboxamide

Guidance literature:: methanesulfonamide; With sodium hydride; In N,N-dimethyl-formamide; at 25 ℃; for 1h;

2-(5-fluoro-2-methyl-phenyl)-spiro(cyclopropane-1,4'-1',2',3',4'-tetrahydroquinoline)-6-carboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 25 - 70 ℃; for 2h;