tert-butyl (R)-2-{[(3-fluorophenyl)methylamino]methyl}pyrrolidine-1-carboxylate

Base Information

Chemical Name:tert-butyl (R)-2-{[(3-fluorophenyl)methylamino]methyl}pyrrolidine-1-carboxylate
CAS No.:1201581-84-1
Molecular Formula:C₁₇H₂₅FN₂O₂
Molecular Weight:308.396
Hs Code.:

Synonyms:tert-butyl (R)-2-{[(3-fluorophenyl)methylamino]methyl}pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl (R)-2-{[(3-fluorophenyl)methylamino]methyl}pyrrolidine-1-carboxylate

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Technology Process of tert-butyl (R)-2-{[(3-fluorophenyl)methylamino]methyl}pyrrolidine-1-carboxylate

There total 6 articles about tert-butyl (R)-2-{[(3-fluorophenyl)methylamino]methyl}pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1201581-83-0
tert-butyl (R)-2-[(3-fluorophenylamino)methyl]pyrrolidine-1-carboxylate

: 74-88-4
methyl iodide

: 1201581-84-1
tert-butyl (R)-2-{[(3-fluorophenyl)methylamino]methyl}pyrrolidine-1-carboxylate

Guidance literature:: tert-butyl (R)-2-[(3-fluorophenylamino)methyl]pyrrolidine-1-carboxylate; With sodium hydride; In tetrahydrofuran; mineral oil; for 0.5h;

methyl iodide; With potassium carbonate; In tetrahydrofuran; mineral oil; at 20 - 50 ℃; for 24h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1201581-84-1
tert-butyl (R)-2-{[(3-fluorophenyl)methylamino]methyl}pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / tert-butyl alcohol / 21 h / 20 °C

2.1: lithium chloride; sodium tetrahydroborate / ethanol; tetrahydrofuran / 19 h / -20 - 20 °C

2.2: 0 °C

3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 2 h / -78 °C / Inert atmosphere

3.2: 2 h / -78 - 20 °C

4.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 12 h / 0 - 20 °C / Inert atmosphere

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h

5.2: 24 h / 20 - 50 °C

With sodium tetrahydroborate; oxalyl dichloride; sodium tris(acetoxy)borohydride; sodium hydride; dimethyl sulfoxide; triethylamine; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane; mineral oil; tert-butyl alcohol;

Reference yield:

: 37784-17-1,59433-50-0
N-(tert-butoxycarbonyl)-D-proline

: 1201581-84-1
tert-butyl (R)-2-{[(3-fluorophenyl)methylamino]methyl}pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium chloride; sodium tetrahydroborate / ethanol; tetrahydrofuran / 19 h / -20 - 20 °C

1.2: 0 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 2 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 - 20 °C

3.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 12 h / 0 - 20 °C / Inert atmosphere

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h

4.2: 24 h / 20 - 50 °C

With sodium tetrahydroborate; oxalyl dichloride; sodium tris(acetoxy)borohydride; sodium hydride; dimethyl sulfoxide; lithium chloride; In tetrahydrofuran; ethanol; dichloromethane; 1,2-dichloro-ethane; mineral oil;