1-[1-(1-phenylcycloheptyl)-4-piperidinyl]-1,3-dihydro-2H-1,3-benzimidazol-2-one

Base Information

• Chemical Name: 1-[1-(1-phenylcycloheptyl)-4-piperidinyl]-1,3-dihydro-2H-1,3-benzimidazol-2-one
• CAS No.: 231960-72-8
• Molecular Formula: C₂₅H₃₁N₃O
• Molecular Weight: 389.541

Synonyms:1-[1-(1-phenylcycloheptyl)-4-piperidinyl]-1,3-dihydro-2H-1,3-benzimidazol-2-one

Chemical Property of 1-[1-(1-phenylcycloheptyl)-4-piperidinyl]-1,3-dihydro-2H-1,3-benzimidazol-2-one

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Technology Process of 1-[1-(1-phenylcycloheptyl)-4-piperidinyl]-1,3-dihydro-2H-1,3-benzimidazol-2-one

There total 4 articles about 1-[1-(1-phenylcycloheptyl)-4-piperidinyl]-1,3-dihydro-2H-1,3-benzimidazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-[4-(2-oxo-2,3-dihydro-1H-1,3-benzimidazol-1-yl)piperidino]-1-cycloheptanecarbonitrile (231961-51-6) + phenylmagnesium bromide → 1-[1-(1-phenylcycloheptyl)-4-piperidinyl]-1,3-dihydro-2H-1,3-benzimidazol-2-one (231960-72-8)

Guidance literature:

In 1,2-dimethoxyethane; at 50 ℃; for 2h;

DOI:10.1080/00397910701845837

Reference yield:

HCl salt of 4-(2-keto-1-benzimidazolinyl)piperidine + ammonium chloride + phenylmagnesium bromide (100-58-3) + cycloheptanone (502-42-1) → 1-[1-(1-phenylcycloheptyl)-4-piperidinyl]-1,3-dihydro-2H-1,3-benzimidazol-2-one (231960-72-8)

Guidance literature:

With potassium cyanide; In tetrahydrofuran; diethyl ether; water;

Reference yield:

ammonium chloride + 4-(2-keto-1-benzimidazolinyl)piperidine (20662-53-7) + phenylmagnesium bromide (100-58-3) + cycloheptanone (502-42-1) → 1-[1-(1-phenylcycloheptyl)-4-piperidinyl]-1,3-dihydro-2H-1,3-benzimidazol-2-one (231960-72-8)

Guidance literature:

With hydrogenchloride; potassium cyanide; In tetrahydrofuran; methanol; diethyl ether; water;

upstream raw materials:

phenylmagnesium bromide

cycloheptanone

1-[4-(2-oxo-2,3-dihydro-1H-1,3-benzimidazol-1-yl)piperidino]-1-cycloheptanecarbonitrile

4-(2-keto-1-benzimidazolinyl)piperidine

Downstream raw materials:

2-Chloro-1-[1-(1-phenylcycloheptyl)-4-piperidinyl]-1H-benzimidazole

3-Methyl-1-[1-(1-phenylcycloheptyl)-4-piperidinyl]-1,3-dihydro-2H-1,3-benzimidazol-2-one

t-Butyl N-(2-{2-Oxo-3-[1-(1-phenylcycloheptyl)-4-piperidinyl]2,3-dihydro-1H-benzimidazol-1-yl}ethyl)carbamate

1-Acetyl-3-[1-(1-phenylcycloheptyl)-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one

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