3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57-nonadecaoxanonapentacontane-1,59-diol

Base Information

• Chemical Name: 3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57-nonadecaoxanonapentacontane-1,59-diol
• CAS No.: 351342-08-0
• Molecular Formula: C₄₀H₈₂O₂₁
• Molecular Weight: 899.078
• Mol file: 351342-08-0.mol

Synonyms:3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57-nonadecaoxanonapentacontane-1,59-diol

Chemical Property of 3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57-nonadecaoxanonapentacontane-1,59-diol

Chemical Property:

Purity/Quality:

99.3% ^*data from raw suppliers

PEG21 90% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: PEG21 is a polymer of ethylene glycol subunits with two terminal hydroxyl groups. The hydroxyl groups can react to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. The water solubility properties of the PEG chain are enhanced with longer PEG chains.
• Uses: Eicosa(ethylene glycol) is used in the synthesis of phospholipid detergent conjugates that may be used for in vitro and in vivo gene delivery and other biopharmaceuticals.

Technology Process of 3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57-nonadecaoxanonapentacontane-1,59-diol

There total 14 articles about 3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57-nonadecaoxanonapentacontane-1,59-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.4%

C54H94O21 → 3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57-nonadecaoxanonapentacontane-1,59-diol (351342-08-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 20h; under 11251.1 - 15001.5 Torr; Autoclave;

DOI:10.1002/anie.201403436

Reference yield: 66.0%

1-(4-(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluorodecyl)phenyl)-2,5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50,53,56,59-icosaoxahenhexacontan-61-ol (1585235-93-3) → 3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57-nonadecaoxanonapentacontane-1,59-diol (351342-08-0)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 65h;

DOI:10.1016/j.tetlet.2014.02.047

Reference yield:

Tetraethylene glycol (112-60-7) → 3,6,9,12,15,18,21,24,27,30,33,36,39,42,45,48,51,54,57-nonadecaoxanonapentacontane-1,59-diol (351342-08-0)

Guidance literature:

Multi-step reaction with 5 steps

1: NaH / tetrahydrofuran / 3 h / 100 °C

2: 62 percent / NaH / tetrahydrofuran / 24 h / Heating

3: 98 percent / hydrogen / Pd/C / ethanol / 24 h / 100 °C / 6080 Torr

4: 73 percent / NaH / tetrahydrofuran / 24 h / Heating

5: 93 percent / hydrogen / Pd/C / ethanol / 24 h / 100 °C / 6080 Torr

With hydrogen; sodium hydride; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1021/jo0617464

upstream raw materials:

1-phenyl-2,5,8,11-tetraoxatridecan-13-yl methanesulfonate

tetraethylene glycol di(p-toluenesulfonate)

Tetraethylene glycol

dodecaethylene glycol

Downstream raw materials:

octacosakis(ethylene glycol)