4-(4-Methylphenyl)but-3-enoic acid

Base Information

Chemical Name:4-(4-Methylphenyl)but-3-enoic acid
CAS No.:127404-74-4
Molecular Formula:C₁₁H₁₂O₂
Molecular Weight:176.215
Hs Code.:
DSSTox Substance ID:DTXSID301278881
Nikkaji Number:J524.492G,J2.492.557I

Synonyms:4-(4-methylphenyl)but-3-enoic acid;127404-74-4;(E)-4-(4-methylphenyl)but-3-enoic acid;SCHEMBL9044093;SCHEMBL9044098;DTXSID301278881;CFA40474;(E)-4-(p-Tolyl)but-3-enoic acid;(3E)-4-(4-Methylphenyl)-3-butenoic acid;(3E)-4-(4-methylphenyl)but-3-enoic acid;EN300-103594;EN300-6492680;Z1374884612

Suppliers and Price of 4-(4-Methylphenyl)but-3-enoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 4-(4-Methylphenyl)but-3-enoic acid

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:176.083729621
Heavy Atom Count:13
Complexity:188

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C=CCC(=O)O
Isomeric SMILES:CC1=CC=C(C=C1)/C=C/CC(=O)O

Technology Process of 4-(4-Methylphenyl)but-3-enoic acid

There total 10 articles about 4-(4-Methylphenyl)but-3-enoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 64-18-6
formic acid

: 58824-48-9
1-(4-methylphenyl)-2-propen-1-ol

: 127404-74-4
(E)-4-(4-tolyl)-3-butenoic acid

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; acetic anhydride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In toluene; at 80 ℃; for 12h; regioselective reaction; Schlenk technique; Inert atmosphere;
DOI:10.1002/chem.201701971

Reference yield: 72.0%

: 104-87-0
4-methyl-benzaldehyde

: 51114-94-4
(2-carboxyethyl)triphenylphosphonium bromide

: 127404-74-4
(E)-4-(4-tolyl)-3-butenoic acid

Guidance literature:: With sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; mineral oil; at 23 ℃; Inert atmosphere;
DOI:10.1021/acs.orglett.9b00587

Reference yield: 71.0%

: 625-38-7
but-3-enoic acid

: 1576-35-8
toluene-4-sulfonic acid hydrazide

: 127404-74-4
(E)-4-(4-tolyl)-3-butenoic acid

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper diacetate; In N,N-dimethyl-formamide; at 100 ℃; for 10h; regioselective reaction; Sealed tube;
DOI:10.1021/acs.orglett.0c03773