3-[1-(cyclohexylacetyl)piperidin-4-yl]-7-[4-(methylsulfonyl)phenyl]-3,4-dihydro-2H-1,4-benzoxazine trifluoroacetate

Base Information

Chemical Name:3-[1-(cyclohexylacetyl)piperidin-4-yl]-7-[4-(methylsulfonyl)phenyl]-3,4-dihydro-2H-1,4-benzoxazine trifluoroacetate
CAS No.:1200575-40-1
Molecular Formula:C₂HF₃O₂*C₂₈H₃₆N₂O₄S
Molecular Weight:610.695
Hs Code.:

Synonyms:3-[1-(cyclohexylacetyl)piperidin-4-yl]-7-[4-(methylsulfonyl)phenyl]-3,4-dihydro-2H-1,4-benzoxazine trifluoroacetate

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Chemical Property of 3-[1-(cyclohexylacetyl)piperidin-4-yl]-7-[4-(methylsulfonyl)phenyl]-3,4-dihydro-2H-1,4-benzoxazine trifluoroacetate

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Technology Process of 3-[1-(cyclohexylacetyl)piperidin-4-yl]-7-[4-(methylsulfonyl)phenyl]-3,4-dihydro-2H-1,4-benzoxazine trifluoroacetate

There total 11 articles about 3-[1-(cyclohexylacetyl)piperidin-4-yl]-7-[4-(methylsulfonyl)phenyl]-3,4-dihydro-2H-1,4-benzoxazine trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1200576-30-2
7-[4-(methylsulfonyl)phenyl]-3-piperidin-4-yl-3,4-dihydro-2H-1,4-benzoxazine.

: 5292-21-7
Cyclohexylacetic acid

: 76-05-1
trifluoroacetic acid

: 1200575-40-1
3-[1-(cyclohexylacetyl)piperidin-4-yl]-7-[4-(methylsulfonyl)phenyl]-3,4-dihydro-2H-1,4-benzoxazine trifluoroacetate

Guidance literature:: 7-[4-(methylsulfonyl)phenyl]-3-piperidin-4-yl-3,4-dihydro-2H-1,4-benzoxazine.; Cyclohexylacetic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 1200576-13-1
tert-butyl 4-(7-bromo-2H-1,4-benzoxazin-3-yl)piperidine-1-carboxylate

: 1200575-40-1
3-[1-(cyclohexylacetyl)piperidin-4-yl]-7-[4-(methylsulfonyl)phenyl]-3,4-dihydro-2H-1,4-benzoxazine trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / ethanol / 6 h

2: sodium hydrogencarbonate; triphenylphosphine / palladium diacetate / ethanol / 80 °C

3: dichloromethane / 0.5 h

4: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 20 °C

With sodium tetrahydroborate; sodium hydrogencarbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; triphenylphosphine; palladium diacetate; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 5676-60-8
6-amino-2-methylbenzoxazole

: 1200575-40-1
3-[1-(cyclohexylacetyl)piperidin-4-yl]-7-[4-(methylsulfonyl)phenyl]-3,4-dihydro-2H-1,4-benzoxazine trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: water; hydrogen bromide; sodium nitrite / 0.17 h / 0 °C

1.2: 0 °C

2.1: hydrogenchloride; water / ethanol / 3 h / 100 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 0.75 h

3.2: 20 °C

4.1: sodium tetrahydroborate / ethanol / 6 h

5.1: sodium hydrogencarbonate; triphenylphosphine / palladium diacetate / ethanol / 80 °C

6.1: dichloromethane / 0.5 h

7.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; sodium tetrahydroborate; water; hydrogen bromide; sodium hydrogencarbonate; potassium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; triphenylphosphine; sodium nitrite; palladium diacetate; In ethanol; dichloromethane; N,N-dimethyl-formamide;