5676-60-8

Basic information

• Product Name: 6-Amino-2-methylbenzoxazole
• Synonyms: 6-BENZOXAZOLAMINE, 2-METHYL-;6-AMINO-2-METHYLBENZOXAZOLE;2-METHYL-6-AMINOBENZOXAZOLE;2-METHYL-1,3-BENZOXAZOL-6-AMINE;2-METHYL-BENZOOXAZOL-6-YLAMINE;2-Methyl-6-benzoxazolamine;2-methylbenzo[d]oxazol-6-amine;2-METHYL-1,3-BENZOXAZOL-6-AMIN (MFCD0379181)
• CAS NO: 5676-60-8
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.16
• Mol File: 5676-60-8.mol
• Article Data: 13

Chemical Properties

• Melting Point: 144-146°C
• Boiling Point: 290.6°Cat760mmHg
• Flash Point: 129.6°C
• Appearance: /
• Density: 1.254g/cm³
• Vapor Pressure: 0.00205mmHg at 25°C
• Refractive Index: 1.658
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 2.71±0.10(Predicted)
• CAS DataBase Reference: 6-Amino-2-methylbenzoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Amino-2-methylbenzoxazole(5676-60-8)
• EPA Substance Registry System: 6-Amino-2-methylbenzoxazole(5676-60-8)

Safety Data

• Statements: 36/37/38-36
• Safety Statements: 26-36/37/39
• RIDADR: 2811
• HazardClass: IRRITANT
• PackingGroup: Ⅲ
• Hazardous Substances Data: 5676-60-8(Hazardous Substances Data)

Usage

Chemical Properties

Light brown powder

InChI:InChI=1/C8H8N2O/c1-5-10-7-3-2-6(9)4-8(7)11-5/h2-4H,9H2,1H3

Upstream product

• 5683-43-2 2-methyl-6-nitrobenzoxazole 
• 95-21-6 2-methyl-1,3-benzoxazole 
• 110-54-3 hexane 
• 7439-89-6 iron 
• 121-88-0 5-Nitro-2-aminophenol 
• 13452-14-7 2-methyl-6-benzoxazole carboxylic acid 

Downstream Products

• 860526-99-4 (4-acetylamino-3-hydroxy-phenyl)-arsonic acid 
• 59997-00-1 N,N'-(hydroxy-p-phenylene)-bis-acetamide 
• 222035-92-9 4-[N'-(2-Methyl-6-oxo-5,6-dihydro-3-oxa-1,5-diaza-s-indacen-7-ylidene)-hydrazino]-benzenesulfonamide 
• 686747-44-4 2,5-dichloro-N-(2-methylbenzooxazol-6-yl)benzenesulfonamide 
• 686747-43-3 N-(2-methylbenzooxazol-6-yl)-4-propylbenzenesulfonamide 
• 686747-42-2 3-chloro-2-methyl-N-(2-methylbenzooxazol-6-yl)benzenesulfonamide 

Relevant articles and documents

Synthesis of 9,10-distyrylanthracene derivative and its one- and two-photon induced emission in solid state

Solid fluorescence plays an important role in optoelectronic devices. In this paper, 9,10-bis(6-dimethylamino benzoxazole styryl)-anthracene (1) was synthesized. 1 displayed a strong emission in solid state (microcrystalline state, amorphous solid state and polymeric thin film) resulted from aggregation-induced emission mechanism, and a large absolute fluorescence quantum yield (?f = 0.65) was obtained. 1 also exhibited up-conversion emission in solid state and a strong yellow emission was observed upon excitation with 800–1064 nm, the quadratic dependence of the fluorescence on the excitation laser intensity confirmed that the up-conversion emission resulted from two-photon process.

NOVEL NICOTINAMIDE DERIVATIVES OR SALTS THEREOF

An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. Th e present invention provides a nicotinamide derivative represented by the follo wing formula (I) (wherein R 1 represents a halogen atom; R 2 represents a C 1-12 alkyl group, a C 2-12 alkenyl group, a C 2-12 alkynyl group, a C 3-8 cycloalkyl g roup, an aryl group, an ar-C 1-6 alkyl group or a heterocyclic group, each opti onally having at least one substituent; R 3 represents an aryl group or a hetero cyclic group each optionally having at least one substituent; and R 4 and R 5 e ach independently represent a hydrogen atom; and R 2 and R 4 may form a cyc lic amino group optionally having at least one substituent together with the ni trogen atom to which they bind) or a salt thereof, and a pharmaceutical comp osition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.

Iron-catalysed, general and operationally simple formal hydrogenation using Fe(OTf)3 and NaBH4

An operationally simple and environmentally benign formal hydrogenation protocol has been developed using highly abundant iron(iii) salts and an inexpensive, bench stable, stoichiometric reductant, NaBH4, in ethanol, under ambient conditions. This reaction has been applied to the reduction of terminal alkenes (22 examples, up to 95% yield) and nitro-groups (26 examples, up to 95% yield). Deuterium labelling studies indicate that this reaction proceeds via an ionic rather than radical mechanism.