C₂₆H₂₃N₃O₂S

Base Information

• Chemical Name: C₂₆H₂₃N₃O₂S
• CAS No.: 1185281-13-3
• Molecular Formula: C₂₆H₂₃N₃O₂S
• Molecular Weight: 441.554
• Mol file: 1185281-13-3.mol

Synonyms:C₂₆H₂₃N₃O₂S

Chemical Property of C₂₆H₂₃N₃O₂S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₆H₂₃N₃O₂S

There total 16 articles about C₂₆H₂₃N₃O₂S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(5-isothiocyanato-2-methylphenyl)-1,7-dimethyl-1,6-naphthyridin-2(1H)-one (1185281-07-5) + acetophenone (98-86-2) → C26H23N3O2S (1185281-13-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h;

Reference yield:

2-(2-methyl-5-nitrophenyl)acetonitrile (409082-11-7) → C26H23N3O2S (1185281-13-3)

Guidance literature:

Multi-step reaction with 7 steps

1.1: water; potassium hydroxide / methanol / 14 h / Reflux

2.1: hydrogenchloride / 1,4-dioxane / 14 h / Reflux

2.2: pH > 12

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 20 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine / 1,4-dioxane; toluene / 0.17 h / 150 °C / Microwave irradiation

6.1: dichloromethane / 1 h / 20 °C

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

With hydrogenchloride; water; hydrogen; sodium hydride; potassium carbonate; potassium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; triphenylphosphine; In 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

ethyl 6-chloro-4-(methylamino)pyridine-3-carboxylate (449811-28-3) → C26H23N3O2S (1185281-13-3)

Guidance literature:

Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / -78 °C

1.2: 20 °C

2.1: manganese(IV) oxide / dichloromethane / 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 100 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine / 1,4-dioxane; toluene / 0.17 h / 150 °C / Microwave irradiation

5.1: dichloromethane / 1 h / 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

With manganese(IV) oxide; lithium aluminium tetrahydride; sodium hydride; potassium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

upstream raw materials:

3-(5-isothiocyanato-2-methylphenyl)-1,7-dimethyl-1,6-naphthyridin-2(1H)-one

acetophenone

2-(2-methyl-5-nitrophenyl)acetonitrile

6-chloro-4-(methylamino)pyridine-3-carbaldehyde

Downstream raw materials:

3-(5-((Z)-1-(methylthio)-3-oxo-3-phenylprop-1-enylamino)-2-methylphenyl)-1,7-dimethyl-1,6-naphthyridin-2(1H)-one