(6,6-dimethyl-4-phenyl-5,6-dihydro-4H-1,2-oxazine-3-yl)methanol

Base Information

• Chemical Name: (6,6-dimethyl-4-phenyl-5,6-dihydro-4H-1,2-oxazine-3-yl)methanol
• CAS No.: 1198015-26-7
• Molecular Formula: C₁₃H₁₇NO₂
• Molecular Weight: 219.283
• Mol file: 1198015-26-7.mol

Synonyms:(6,6-dimethyl-4-phenyl-5,6-dihydro-4H-1,2-oxazine-3-yl)methanol

Chemical Property of (6,6-dimethyl-4-phenyl-5,6-dihydro-4H-1,2-oxazine-3-yl)methanol

Chemical Property:

Purity/Quality:

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Technology Process of (6,6-dimethyl-4-phenyl-5,6-dihydro-4H-1,2-oxazine-3-yl)methanol

There total 12 articles about (6,6-dimethyl-4-phenyl-5,6-dihydro-4H-1,2-oxazine-3-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

acetic acid (64-19-7,77671-22-8) + 6,6-dimethyl-3-methylene-4-phenyl-2-(trimethylsilyloxy)-2,3,5,6-tetrahydro-4H-[1,2]oxazine (638133-16-1) → (6,6-dimethyl-4-phenyl-5,6-dihydro-4H-1,2-oxazine-3-yl)methanol (1198015-26-7) + C15H20O4 + (6,6-dimethyl-4-phenyl-5,6-dihydro-4H-1,2-oxazin-3-yl)methyl acetate

Guidance literature:

In acetonitrile; at 20 ℃; for 2h; regioselective reaction;

DOI:10.1002/ejoc.201701266

Reference yield: 33.0%

6,6-dimethyl-3-methylene-4-phenyl-2-(trimethylsilyloxy)-2,3,5,6-tetrahydro-4H-[1,2]oxazine (638133-16-1) → (6,6-dimethyl-4-phenyl-5,6-dihydro-4H-1,2-oxazine-3-yl)methanol (1198015-26-7) + 3-(bromomethyl)-6,6-dimethyl-4-phenyl-5,6-dihydro-4H-1,2-oxazine (742062-86-8)

Guidance literature:

With hydrogen bromide; In tetrahydrofuran; dichloromethane; water; at 20 ℃; for 1.5h; Reagent/catalyst;

DOI:10.1002/ejoc.201403083

Reference yield: 27.0%

6,6-dimethyl-3-methylene-4-phenyl-2-(trimethylsilyloxy)-2,3,5,6-tetrahydro-4H-[1,2]oxazine (638133-16-1) → (6,6-dimethyl-4-phenyl-5,6-dihydro-4H-1,2-oxazine-3-yl)methanol (1198015-26-7) + C13H17NO2 (1313227-89-2)

Guidance literature:

With aluminum tri-bromide; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1002/ejoc.201403083

upstream raw materials:

(6,6-dimethyl-4-phenyl-5,6-dihydro-4H-1,2-oxazin-3-yl)methyl 2,2,2-trifluoroacetate

6,6-dimethyl-5,6-dihydro-3-methyl-4-phenyl-1,2-oxazine N-oxide

6,6-dimethyl-3-methylene-4-phenyl-2-(trimethylsilyloxy)-2,3,5,6-tetrahydro-4H-[1,2]oxazine

acetic acid

Downstream raw materials:

6,6-dimethyl-3-((tert-butyldimethylsilyloxy)methyl)-4-phenyl-5,6-dihydro-4H-[1,2]oxazine