(R)-2-(4-bromophenyl)-2-methyl-4-(1-phenyl-1H-tetrazol-5-ylsulfonyl)butanal

Base Information

Chemical Name:(R)-2-(4-bromophenyl)-2-methyl-4-(1-phenyl-1H-tetrazol-5-ylsulfonyl)butanal
CAS No.:1342313-04-5
Molecular Formula:C₁₈H₁₇BrN₄O₃S
Molecular Weight:449.328
Hs Code.:

Synonyms:(R)-2-(4-bromophenyl)-2-methyl-4-(1-phenyl-1H-tetrazol-5-ylsulfonyl)butanal

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-(4-bromophenyl)-2-methyl-4-(1-phenyl-1H-tetrazol-5-ylsulfonyl)butanal

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Technology Process of (R)-2-(4-bromophenyl)-2-methyl-4-(1-phenyl-1H-tetrazol-5-ylsulfonyl)butanal

There total 6 articles about (R)-2-(4-bromophenyl)-2-methyl-4-(1-phenyl-1H-tetrazol-5-ylsulfonyl)butanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1154397-00-8
1-phenyl-5-(vinylsulfonyl)-1H-tetrazole

: 40460-91-1
2-(4-bromophenyl)propanal

: 1342313-04-5
(R)-2-(4-bromophenyl)-2-methyl-4-(1-phenyl-1H-tetrazol-5-ylsulfonyl)butanal

Guidance literature:: With 9-epi-9-amino-9-deoxyquinine; 4-nitro-benzoic acid; In chloroform; at 20 ℃; for 48h; optical yield given as %ee; enantioselective reaction;
DOI:10.1039/c1cc14909a

Reference yield:

: 1-bromo-4-(1-methoxyprop-1-en-2-yl)-benzene

: 1342313-04-5
(R)-2-(4-bromophenyl)-2-methyl-4-(1-phenyl-1H-tetrazol-5-ylsulfonyl)butanal

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen bromide / water; acetone

2: 9-epi-9-amino-9-deoxyquinine; 4-nitro-benzoic acid / chloroform / 48 h / 20 °C

With 9-epi-9-amino-9-deoxyquinine; hydrogen bromide; 4-nitro-benzoic acid; In chloroform; water; acetone; 2: Michael addition;
DOI:10.1039/c1cc14909a

Reference yield:

: 1153358-38-3
5-((2-chloroethyl)thio)-1-phenyl-1H-tetrazole

: 1342313-04-5
(R)-2-(4-bromophenyl)-2-methyl-4-(1-phenyl-1H-tetrazol-5-ylsulfonyl)butanal

Guidance literature:: Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 72 h / 20 °C

2: triethylamine / tetrahydrofuran / 0.5 h

3: 9-epi-9-amino-9-deoxyquinine; 4-nitro-benzoic acid / chloroform / 48 h / 20 °C

With 9-epi-9-amino-9-deoxyquinine; triethylamine; 3-chloro-benzenecarboperoxoic acid; 4-nitro-benzoic acid; In tetrahydrofuran; dichloromethane; chloroform; 3: Michael addition;
DOI:10.1039/c1cc14909a