40460-91-1

Basic information

• Product Name: 2-(4-bromophenyl)propanal
• Synonyms: 2-(4-bromophenyl)propanal
• CAS NO: 40460-91-1
• Molecular Weight: 213.074
• Mol File: 40460-91-1.mol
• Article Data: 43

Chemical Properties

• CAS DataBase Reference: 2-(4-bromophenyl)propanal(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-bromophenyl)propanal(40460-91-1)
• EPA Substance Registry System: 2-(4-bromophenyl)propanal(40460-91-1)

Safety Data

• Hazardous Substances Data: 40460-91-1(Hazardous Substances Data)

Upstream product

• 117125-64-1 3-(4-Bromo-phenyl)-3-methyl-oxirane-2-carbonitrile 
• 99-90-1 para-bromoacetophenone 
• 105-39-5 chloroacetic acid ethyl ester 
• 2039-82-9 1-bromo-4-ethenyl-benzene 
• 201230-82-2 carbon monoxide 
• 111914-79-5 (+/-)-2-(4-bromophenyl)propionic acid ethyl ester 
• 589-87-7 1,4-bromoiodobenzene 
• 107-18-6 allyl alcohol 
• 41841-16-1 (4-bromo-phenyl)-acetic acid methyl ester 
• 83636-46-8 methyl 2-(4-bromophenyl)propanoate 
• 81310-74-9 4-bromo-α-methyl-benzeneethanol 
• 6888-79-5 4-bromo-α-methylstyrene 
• 80909-78-0 p-bromo-α-methylstyrene oxide 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 40460-74-0 [(E)-2-(4-Bromo-phenyl)-propenyl]-(4-methoxy-phenyl)-amine 
• 40460-63-7 2-(4-Bromphenyl)-propionaldehyd-methylimin 
• 40460-69-3 4-Brom-hydratropaaldehyd-benzylimin 
• 1233867-67-8 4-(4-bromophenyl)-5-butyl-4-methyl-2-cyclohexen-1-one 
• 1233867-63-4 4-(4-bromophenyl)-4,5-dimethyl-2-cyclohexen-1-one 
• 1369965-76-3 C₁₆H₁₅BrOS₂ 
• 1205552-47-1 C₁₁H₁₁BrO₂ 
• 1416571-04-4 C₁₁H₁₁BrO₂ 
• 1245633-09-3 diethyl 1-(1-oxo-2-(4-bromophenyl)propan-2-yl)hydrazine-1,2-dicarboxylate 

Relevant articles and documents

Chemical space exploration of oxetanes

This paper focuses on new derivatives bearing an oxetane group to extend accessible chemical space for further identification of kinase inhibitors. The ability to modulate kinase activity represents an important therapeutic strategy for the treatment of h

Synthesis of rac-ɑ-aryl propionaldehydes via branched-selective hydroformylation of terminal arylalkenes using water-soluble Rh-PNP catalyst

This work detailed the preparation of a class of water-soluble PNP ligands that differed by the nature of the substitute on phenyl ring of ligands. These ligands were incorporated into water-soluble rhodium-PNP complex catalysts that were used to regioselective hydroformylation of a series of terminal arylalkenes, providing efficient access to rac-α-aryl propionaldehydes in good to excellent yield (up to 97%) and branched-regioselectivity (up to 40:1 b/l ratio). Furthermore, gram-scale and diverse synthetic transformation demonstrated synthetic application of this methodology for non-steroidal antiinflammatory drugs.

An Asymmetric SN2 Dynamic Kinetic Resolution

The SN2 reaction exhibits the classic Walden inversion, indicative of the stereospecific backside attack of the nucleophile on the stereogenic center. Observation of the inversion of the stereocenter provides evidence for an SN2-type displacement. However, this maxim is contingent on substitution proceeding on a discrete stereocenter. Here we report an SN2 reaction that leads to enantioenrichment of product despite starting from a racemic mixture of starting material. The enantioconvergent reaction proceeds through a dynamic Walden cycle, involving an equilibrating mixture of enantiomers, initiated by a chiral aminocatalyst and terminated by a stereoselective SN2 reaction at a tertiary carbon to provide a quaternary carbon stereocenter. A combination of computational, kinetic, and empirical studies elucidates the multifaceted role of the chiral organocatalyst to provide a model example of the Curtin-Hammett principle. These examples challenge the notion of enantioenriched products exclusively arising from predefined stereocenters when operating through an SN2 mechanism. Based on these principles, examples are included to highlight the generality of the mechanism. We anticipate the asymmetric SN2 dynamic kinetic resolution to be used for a variety of future reactions.