(2S)-2-(3,5-bis(trifluoromethyl)phenyl)-N-[4-(4-fluoro-2-methylphenyl)-6-(2-hydroxymethylpyrrolidin-1-yl)pyridin-3-yl]-N-methylisobutyramide

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Chemical Name:(2S)-2-(3,5-bis(trifluoromethyl)phenyl)-N-[4-(4-fluoro-2-methylphenyl)-6-(2-hydroxymethylpyrrolidin-1-yl)pyridin-3-yl]-N-methylisobutyramide
CAS No.:825640-97-9
Molecular Formula:C₃₀H₃₀F₇N₃O₂
Molecular Weight:597.576
Hs Code.:

Synonyms:(2S)-2-(3,5-bis(trifluoromethyl)phenyl)-N-[4-(4-fluoro-2-methylphenyl)-6-(2-hydroxymethylpyrrolidin-1-yl)pyridin-3-yl]-N-methylisobutyramide

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Chemical Property of (2S)-2-(3,5-bis(trifluoromethyl)phenyl)-N-[4-(4-fluoro-2-methylphenyl)-6-(2-hydroxymethylpyrrolidin-1-yl)pyridin-3-yl]-N-methylisobutyramide

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Technology Process of (2S)-2-(3,5-bis(trifluoromethyl)phenyl)-N-[4-(4-fluoro-2-methylphenyl)-6-(2-hydroxymethylpyrrolidin-1-yl)pyridin-3-yl]-N-methylisobutyramide

There total 1 articles about (2S)-2-(3,5-bis(trifluoromethyl)phenyl)-N-[4-(4-fluoro-2-methylphenyl)-6-(2-hydroxymethylpyrrolidin-1-yl)pyridin-3-yl]-N-methylisobutyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 825643-73-0
2-(3,5-bis(trifluoromethyl)phenyl)-N-(6-chloro-4-(4-fluoro-2-methylphenyl)pyridin-3-yl)-N,2-dimethylpropanamide

: 23356-96-9
(S)-1-Pyrrolidin-2-yl-methanol

: 825640-97-9
(2S)-2-(3,5-bis(trifluoromethyl)phenyl)-N-[4-(4-fluoro-2-methylphenyl)-6-(2-hydroxymethylpyrrolidin-1-yl)pyridin-3-yl]-N-methylisobutyramide

Guidance literature:: With potassium carbonate; In dimethyl sulfoxide; at 180 ℃; for 0.5h; Microwave irradiation;

Reference yield: 40.0%

: 825640-97-9
(2S)-2-(3,5-bis(trifluoromethyl)phenyl)-N-[4-(4-fluoro-2-methylphenyl)-6-(2-hydroxymethylpyrrolidin-1-yl)pyridin-3-yl]-N-methylisobutyramide

: (S)-dimethyl-carbamic acid 1-[5-{[2-(3,5-bis-trifluoromethyl-phenyl)-2-methyl-propionyl]-methyl-amino}-4-(4-fluoro-2-methyl-phenyl)-pyridin-2-yl]-pyrrolidin-2-ylmethyl ester

Guidance literature:: 1,1,3,3-tetramethyl-2-thiourea; With methyl iodide; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 0.833333h;

(2S)-2-(3,5-bis(trifluoromethyl)phenyl)-N-[4-(4-fluoro-2-methylphenyl)-6-(2-hydroxymethylpyrrolidin-1-yl)pyridin-3-yl]-N-methylisobutyramide; With sodium hydride; In DMF (N,N-dimethyl-formamide); hexane; at 20 ℃; for 1h;