benzyl (5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl) methyl hexanoate

Base Information

Chemical Name:benzyl (5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl) methyl hexanoate
CAS No.:201210-71-1
Molecular Formula:C₁₈H₁₉FN₂O₆
Molecular Weight:378.357
Hs Code.:

Synonyms:benzyl (5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl) methyl hexanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of benzyl (5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl) methyl hexanoate

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Technology Process of benzyl (5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl) methyl hexanoate

There total 4 articles about benzyl (5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl) methyl hexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 51-21-8
5-fluorouracil

: 87343-30-4
benzyl chloromethyl adipate

: 201210-71-1
benzyl (5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl) methyl hexanoate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; for 16h; Ambient temperature;
DOI:10.1021/jo971076p

Reference yield:

: 40542-90-3
adipic acid monobenzyl ester

: 201210-71-1
benzyl (5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl) methyl hexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / Cs₂CO₃ / dimethylformamide / 1.) room temperature, 30 min; 70 deg C, 15 min, 2.) room temperature, 3 h; 70 deg C, 15 min

2: 1.) SO₂Cl₂, 2.) cis-4-cyclohexene-1,2-dicarboxylic acid / 1.) CH₂Cl₂, room temperature, 1 h, 2.) 1 h

3: 63 percent / Et₃N / dimethylformamide / 16 h / Ambient temperature

With sulfuryl dichloride; cis-1,2,3,6-tetrahydrophthalic acid; caesium carbonate; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jo971076p

Reference yield:

: 201210-69-7
Hexanedioic acid benzyl ester phenylsulfanylmethyl ester

: 201210-71-1
benzyl (5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl) methyl hexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) SO₂Cl₂, 2.) cis-4-cyclohexene-1,2-dicarboxylic acid / 1.) CH₂Cl₂, room temperature, 1 h, 2.) 1 h

2: 63 percent / Et₃N / dimethylformamide / 16 h / Ambient temperature

With sulfuryl dichloride; cis-1,2,3,6-tetrahydrophthalic acid; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jo971076p