C₁₄H₁₆FN₃

Base Information

• Chemical Name: C₁₄H₁₆FN₃
• CAS No.: 1261118-41-5
• Molecular Formula: C₁₄H₁₆FN₃
• Molecular Weight: 245.3
• Mol file: 1261118-41-5.mol

Synonyms:C₁₄H₁₆FN₃

Chemical Property of C₁₄H₁₆FN₃

Chemical Property:

Purity/Quality:

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Technology Process of C₁₄H₁₆FN₃

There total 2 articles about C₁₄H₁₆FN₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

C22H22FN3O2 (1261118-40-4) → C14H16FN3 (1261118-41-5)

Guidance literature:

With methanesulfonic acid; acetic acid; for 12h; Sealed tube; Heating;

DOI:10.1021/jm300041e

Reference yield:

C18H16FN3O2 (1261118-48-2) → C14H16FN3 (1261118-41-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 48 h / 20 - 40 °C

2: methanesulfonic acid; acetic acid / 12 h / Sealed tube; Heating

With methanesulfonic acid; potassium carbonate; acetic acid; potassium iodide; In N,N-dimethyl-formamide;

DOI:10.1021/jm300041e

Reference yield: 57.0%

BOC-glycine (4530-20-5) + C14H16FN3 (1261118-41-5) → tert-butyl 2-(3-bromo-2-(4-fluorophenyl)-6,6-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-2-oxoethylcarbamate (1261118-06-2)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm300041e

upstream raw materials:

C₁₈H₁₆FN₃O₂

C₂₂H₂₂FN₃O₂

Downstream raw materials:

tert-butyl 2-(3-bromo-2-(4-fluorophenyl)-6,6-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-2-oxoethylcarbamate

C₂₁H₂₆BrFN₄O₃

2-amino-1-(2-(4-fluorophenyl)-3-(4-fluorophenylamino)-6,6-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-ethanone