4-(2H-TETRAZOL-5-YL)-PHENYLBORONIC ACID

Base Information

• Chemical Name: 4-(2H-TETRAZOL-5-YL)-PHENYLBORONIC ACID
• CAS No.: 179942-55-3
• Molecular Formula: C7H7 B N4 O2
• Molecular Weight: 189.969
• Hs Code.: 2933990090
• Mol file: 179942-55-3.mol

Synonyms:Boronicacid, [4-(1H-tetrazol-5-yl)phenyl]- (9CI)

Chemical Property of 4-(2H-TETRAZOL-5-YL)-PHENYLBORONIC ACID

Chemical Property:

• Vapor Pressure: 4.93E-10mmHg at 25°C
• Melting Point: 174-179°C (Decomposition)
• Refractive Index: 1.641
• Boiling Point: 480.3°Cat760mmHg
• PKA: 4.11±0.10(Predicted)
• Flash Point: 244.2°C
• PSA: 94.92000
• Density: 1.51g/cm³
• LogP: -1.45350
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(2H-Tetrazol-5-yl)phenylboronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Product is used as a reactant for palladium-catalyzed carbon-carbon bond formation (Suzuki-Miyuara reaction).

Technology Process of 4-(2H-TETRAZOL-5-YL)-PHENYLBORONIC ACID

There total 1 articles about 4-(2H-TETRAZOL-5-YL)-PHENYLBORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

→ (4-(1H-tetrazol-5-yl)phenyl)boronic acid (179942-55-3)

Guidance literature:

Reference yield: 84.0%

(4-(1H-tetrazol-5-yl)phenyl)boronic acid (179942-55-3) + 2-Chloro-6-methoxy-3-methylquinoline (123990-76-1) → 2-(4-(1H-tetrazol-5-yl)phenyl)-6-methoxy-3-methylquinoline (1371588-17-8)

Guidance literature:

(4-(1H-tetrazol-5-yl)phenyl)boronic acid; 2-Chloro-6-methoxy-3-methylquinoline; With 2-(2-methoxyethoxy)ethyl alcohol; potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In water; at 150 ℃; for 1.5h; Inert atmosphere; microwave;

With sodium hydroxide; In water;

With hydrogenchloride; In water; pH=4;

Reference yield: 79.0%

(4-(1H-tetrazol-5-yl)phenyl)boronic acid (179942-55-3) + N-(3-(5-bromo-1H-pyrazolo[3,4-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide (1246614-23-2) → N-[2,4-difluoro-3-[5-[4-(1H-tetrazol-5-yl)phenyl]-1H-pyrazolo[3,4-b]pyridine-3-carbonyl]phenyl]propane-1-sulfonamide

Guidance literature:

With C₄₇H₆₃NO₃PPdS; potassium carbonate; In 1,4-dioxane; water; at 120 ℃; for 0.5h; Microwave irradiation;

DOI:10.1016/j.ejmech.2021.113371

Downstream raw materials:

C₁₁H₇ClN₆

3-(3-(1H-tetrazol-5-yl)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole-6-carbaldehyde

1-[(4-methylphenyl)sulfonyl]-5-phenyl-3-[4-(1H-tetrazol-5-yl)phenyl]-1H-pyrrolo[2,3-b]pyridine

6-(4-(2H-tetrazol-5-yl)phenyl)-1-(cyclohexylmethyl)-1H-imidazo[4,5-b]pyrazin-2(3H)-one

Refernces