(8-fluoroquinolin-3-yl)boronic acid

Base Information

• Chemical Name: (8-fluoroquinolin-3-yl)boronic acid
• CAS No.: 1207750-07-9
• Molecular Formula: C₉H₇BFNO₂
• Molecular Weight: 190.969
• Hs Code.: 2933499090
• Mol file: 1207750-07-9.mol

Synonyms:(8-fluoroquinolin-3-yl)boronic acid

Chemical Property of (8-fluoroquinolin-3-yl)boronic acid

Chemical Property:

• Boiling Point: 403.2±48.0 °C(Predicted)
• PKA: 6.71±0.30(Predicted)
• Density: 1.37±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

8-Fluoroquinolin-3-ylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 8-Fluoroquinolin-3-ylboronic acid

Technology Process of (8-fluoroquinolin-3-yl)boronic acid

There total 2 articles about (8-fluoroquinolin-3-yl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

8-fluoro-3-iodoquinoline (866782-59-4) → (8-fluoroquinolin-3-yl)boronic acid (1207750-07-9)

Guidance literature:

8-fluoro-3-iodoquinoline; With n-butyllithium; butyl magnesium bromide; In tetrahydrofuran; hexane; for 2h; Cooling with salt-ice bath; Inert atmosphere;

With Trimethyl borate; for 2h;

Reference yield: 91.0%

8-fluoro-3-iodoquinoline (866782-59-4) + Trimethyl borate (121-43-7,63156-11-6) → (8-fluoroquinolin-3-yl)boronic acid (1207750-07-9)

Guidance literature:

8-fluoro-3-iodoquinoline; With n-butyllithium; butyl magnesium bromide; In tetrahydrofuran; hexane; for 1.5h; Cooling with ice; Inert .atmosphere;

Trimethyl borate; In tetrahydrofuran; hexane;

Reference yield:

(8-fluoroquinolin-3-yl)boronic acid (1207750-07-9) + 7-chloro-N-[(1R)-1-(4-fluorophenyl)-3-hydroxypropyl]-5-oxo-5,6-dihydroimidazo[1,2-c]pyrimidine-2-carboxamide → N-[(1R)-1-(4-fluorophenyl)-3-hydroxypropyl]-7-(8-fluoroquinolin-3-yl)-5-oxo-5,6-dihydroimidazo[1,2-c]pyrimidine-2-carboxamide

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 110 ℃; for 0.75h; Inert atmosphere;

upstream raw materials:

8-fluoro-3-iodoquinoline

Trimethyl borate

Refernces

• 1、 -. "NITROGENATED HETEROCYCLIC DERIVATIVE, AND AGRICULTURAL OR HORTICULTURAL BACTERICIDAL AGENT". Page/Page column 51-52. . Retrieved 2011/05/05.