ethyl 3-(2-{[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate

Base Information

Chemical Name:ethyl 3-(2-{[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate
CAS No.:1095274-38-6
Molecular Formula:C₁₇H₂₀F₃N₃O₅
Molecular Weight:403.358
Hs Code.:

Synonyms:ethyl 3-(2-{[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate

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Chemical Property of ethyl 3-(2-{[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate

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Technology Process of ethyl 3-(2-{[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate

There total 3 articles about ethyl 3-(2-{[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 30866-24-1
ethyl 3-hydrazino-3-oxopropanoate

: 250682-08-7
3-(4-morpholin-4-yl)-5-trifluoromethylbenzoic acid

: 1095274-38-6
ethyl 3-(2-{[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 220954-14-3
3-(4-morpholinyl)-5-(trifluoromethyl)-benzonitrile

: 1095274-38-6
ethyl 3-(2-{[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water / 24 h / Heating / reflux

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 149793-69-1
3-fluoro-5-trifluoromethyl-benzonitrile

: 1095274-38-6
ethyl 3-(2-{[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 36 h / 80 °C

2: sodium hydroxide / ethanol; water / 24 h / Heating / reflux

3: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;