ethyl {5-[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}acetate

Base Information

Chemical Name:ethyl {5-[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}acetate
CAS No.:1095274-39-7
Molecular Formula:C₁₇H₁₈F₃N₃O₄
Molecular Weight:385.343
Hs Code.:

Synonyms:ethyl {5-[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}acetate

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Chemical Property of ethyl {5-[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}acetate

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Technology Process of ethyl {5-[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}acetate

There total 4 articles about ethyl {5-[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1095274-38-6
ethyl 3-(2-{[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate

: 1095274-39-7
ethyl {5-[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}acetate

Guidance literature:: With Burgess Reagent; In dichloromethane; at 120 ℃; for 0.166667h; Microwave irradition;

Reference yield:

: 250682-08-7
3-(4-morpholin-4-yl)-5-trifluoromethylbenzoic acid

: 1095274-39-7
ethyl {5-[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 20 °C

2: Burgess Reagent / dichloromethane / 0.17 h / 120 °C / Microwave irradition

With 4-methyl-morpholine; Burgess Reagent; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 220954-14-3
3-(4-morpholinyl)-5-(trifluoromethyl)-benzonitrile

: 1095274-39-7
ethyl {5-[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}acetate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol; water / 24 h / Heating / reflux

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 20 °C

3: Burgess Reagent / dichloromethane / 0.17 h / 120 °C / Microwave irradition

With 4-methyl-morpholine; sodium hydroxide; Burgess Reagent; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;