{5-[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}acetaic acid

Base Information

Chemical Name:{5-[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}acetaic acid
CAS No.:1095274-40-0
Molecular Formula:C₁₅H₁₄F₃N₃O₄
Molecular Weight:357.289
Hs Code.:

Synonyms:{5-[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}acetaic acid

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Chemical Property of {5-[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}acetaic acid

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Technology Process of {5-[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}acetaic acid

There total 5 articles about {5-[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}acetaic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1095274-39-7
ethyl {5-[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}acetate

: 1095274-40-0
{5-[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}acetaic acid

Guidance literature:: ethyl {5-[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}acetate; With sodium hydroxide; water; In ethanol; at 20 ℃; for 1h;

With hydrogenchloride; In water;

Reference yield:

: 220954-14-3
3-(4-morpholinyl)-5-(trifluoromethyl)-benzonitrile

: 1095274-40-0
{5-[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}acetaic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / ethanol; water / 24 h / Heating / reflux

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 20 °C

3: Burgess Reagent / dichloromethane / 0.17 h / 120 °C / Microwave irradition

4: sodium hydroxide; water / ethanol / 1 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; Burgess Reagent; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1095274-38-6
ethyl 3-(2-{[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]carbonyl}hydrazino)-3-oxopropanoate

: 1095274-40-0
{5-[3-(4-morpholinyl)-5-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2-yl}acetaic acid

Guidance literature:: Multi-step reaction with 2 steps

1: Burgess Reagent / dichloromethane / 0.17 h / 120 °C / Microwave irradition

2: sodium hydroxide; water / ethanol / 1 h / 20 °C

With sodium hydroxide; Burgess Reagent; water; In ethanol; dichloromethane;