3-(benzo[b]thiophene-2-carboxamido)-4-(4-chlorophenylcarbamoyl)benzoic acid

Base Information

• Chemical Name: 3-(benzo[b]thiophene-2-carboxamido)-4-(4-chlorophenylcarbamoyl)benzoic acid
• CAS No.: 1374777-73-7
• Molecular Formula: C₂₃H₁₅ClN₂O₄S
• Molecular Weight: 450.902

Synonyms:3-(benzo[b]thiophene-2-carboxamido)-4-(4-chlorophenylcarbamoyl)benzoic acid

Chemical Property of 3-(benzo[b]thiophene-2-carboxamido)-4-(4-chlorophenylcarbamoyl)benzoic acid

Chemical Property:

Purity/Quality:

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Technology Process of 3-(benzo[b]thiophene-2-carboxamido)-4-(4-chlorophenylcarbamoyl)benzoic acid

There total 3 articles about 3-(benzo[b]thiophene-2-carboxamido)-4-(4-chlorophenylcarbamoyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

benzothiophene-2-carboxylic acid chloride (39827-11-7) + C14H11ClN2O3 (1374779-41-5) → 3-(benzo[b]thiophene-2-carboxamido)-4-(4-chlorophenylcarbamoyl)benzoic acid (1374777-73-7)

Guidance literature:

In tetrahydrofuran; for 12h; Reflux;

Reference yield:

2,4-dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-7-carboxylic acid (77423-14-4) → 3-(benzo[b]thiophene-2-carboxamido)-4-(4-chlorophenylcarbamoyl)benzoic acid (1374777-73-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap / N,N-dimethyl-formamide / 10 h / 70 - 80 °C

2: tetrahydrofuran / 12 h / Reflux

dmap; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

3-aminoterephthalic acid (10312-55-7) → 3-(benzo[b]thiophene-2-carboxamido)-4-(4-chlorophenylcarbamoyl)benzoic acid (1374777-73-7)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran / 24 h / Reflux

2: dmap / N,N-dimethyl-formamide / 10 h / 70 - 80 °C

3: tetrahydrofuran / 12 h / Reflux

dmap; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

benzothiophene-2-carboxylic acid chloride

C₁₄H₁₁ClN₂O₃

3-aminoterephthalic acid

2,4-dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-7-carboxylic acid

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