77423-14-4

Usage

Uses

Used in Pharmaceutical Industry:
4-Carboxylic-isatoic anhydride is used as an intermediate in the synthesis of pharmaceuticals for its potential applications in the development of new drugs. Its reactivity allows it to be a key component in creating a variety of medicinal compounds.
Used in Dye and Pigment Industry:
In the dye and pigment industry, 4-Carboxylic-isatoic anhydride is utilized as an intermediate, contributing to the production of various dyes and pigments due to its chemical properties that facilitate color development and stability.
Used in Organic Chemistry as a Building Block:
4-Carboxylic-isatoic anhydride serves as a building block in organic chemistry for the preparation of a wide range of organic compounds. Its ability to participate in numerous chemical reactions makes it instrumental in the synthesis of complex organic molecules for various applications.

InChI:InChI=1/C9H5NO5/c11-7(12)4-1-2-5-6(3-4)10-9(14)15-8(5)13/h1-3H,(H,10,14)(H,11,12)

Upstream product

• 75-44-5 phosgene 
• 10312-55-7 3-aminoterephthalic acid 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 503-38-8 trichloromethyl chloroformate 
• 5372-81-6 dimethyl aminoterephthalate 

Downstream Products

• 1261594-20-0 methyl 3-benzyl-1-methyl-5-oxo-2,3,4,5-tetrahydro-1H-benzo[d][1,3]diazepine-8-carboxylate 
• 942152-81-0 3-benzyl 7-methyl 4-hydroxy-1-methyl-2-oxo-1,2-dihydroquinoline-3,7-dicarboxylate 
• 1374779-41-5 C₁₄H₁₁ClN₂O₃ 
• 218590-81-9 1-ethyl 2-aminoterephthalate 
• 1391926-99-0 C₂₂H₁₄N₂O₉ 
• 1391926-96-7 1-phenyl 2-aminoterephthalate 
• 1374778-41-2 3-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-(3-cyanophenylcarbamoyl)benzoic acid 
• 1374779-57-3 3-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-(3-chlorophenylcarbamoyl)benzoic acid tert-butyl ester 
• 1374779-56-2 C₁₈H₁₉ClN₂O₃ 
• 1374778-19-4 3-(3-chlorobenzo[b]thiophene-2-carboxamido)-4-(3-chlorophenylcarbamoyl)benzoic acid 
• 1374777-73-7 3-(benzo[b]thiophene-2-carboxamido)-4-(4-chlorophenylcarbamoyl)benzoic acid 
• 1374779-55-1 3-amino-N-(3-chlorophenylcarbamoyl)benzoic acid 
• 1374779-49-3 C₁₅H₁₁N₃O₃ 
• 167903-04-0 3-amino-4-(methylamino)carbonylbenzoic acid 

Relevant academic research and scientific papers

MODIFIED PROTEINS AND PROTEIN DEGRADERS

Provided herein are compounds, pharmaceutical compositions, and methods for binding or degrading target proteins. Further provided herein are compounds having a DNA damage-binding protein 1 (DDB1) binding moiety. Some such embodiments include a linker. Some such embodiments include a target protein binding moiety. Further provided herein are ligand-DDB1 complexes. Further provided herein are in vivo modified DDB1 proteins.

SUBSTITUTED 1,1'-BIPHENYL COMPOUNDS AND METHODS USING SAME

The present invention includes substituted 1,1'-biphenyl compounds, analogues thereof, and compositions comprising the same. In one aspect, the compounds contemplated in the invention can be used to treat, ameliorate, or prevent hepatitis B virus (HBV) and/or hepatitis D virus (HDV) infections in a patient. In another aspect, the compounds contemplated in the invention can be used to treat, ameliorate, and/or prevent cancer in a patient.

METHODS AND COMPOSITIONS FOR DRUGS TO TREAT OPHTHALMIC DISEASES

The presently disclosed subject matter is directed to compositions and methods for treating CaMKK2-mediated ophthalmic diseases, including but not limited to 1) ocular surface inflammatory diseases (OSIDs), including but not limited to ocular graft versus

COMPOUNDS AND METHODS FOR MODULATING RNA FUNCTION

The present invention provides compounds, compositions thereof, and methods of using the same.

COMPOUNDS AND METHODS OF TREATING RNA-MEDIATED DISEASES

The present invention provides compounds, compositions thereof, and methods of using the same.

METHOD OF PRODUCING NITROGEN-CONTAINING HETEROCYCLIC COMPOUND

PROBLEM TO BE SOLVED: To provide a chemical compound production method realizing easy and high-yield production of a nitrogen-containing heterocyclic compound useful as a synthetic intermediate and the like in many fields such as medicine, agriculture and synthetic resin additives. SOLUTION: In the production method, an ortho-substituted benzene azide derivative represented by formula (1) is reacted with carbon dioxide in the presence of a reductant to obtain a compound represented by formula (2). [R is H and/or a substituent; A is an intramolecular cyclizable group; and B is a divalent linking group of C, N and O. COPYRIGHT: (C)2016,JPOandINPIT

NEUROTRYPSIN INHIBITORS

The invention relates to acylamino-phthalic acid amides and related compounds of formula (I) wherein A is -CONR3R4,-NR5COR6, -NHR7, -OR8, -mR9, -CH2NRI0R11, -(CH2)2-R12, -CH=CH-R12, -C=C-R12, optionally substituted phenyl, optionally substituted thiophenyl, or optionally substituted 1,2,3-triazol-4-yl, W is hydrogen, hydroxy or carboxymethoxy, Y is carboxy, methoxycarbonyl or 2H-tetrazol-5-yl, and the various substituents R have the meanings indicated in the description. These compounds are useful for the treatment and/or prophylaxis of skeletal muscle atrophy, schizophrenia and Alzheimer?s disease, and as cognitive enhancers.

Chemoselective ligation of sulfinic acids with aryl-nitroso compounds

Making a comeback: The inefficient condensation of sulfinic acid and aryl nitroso compounds has been transformed into a chemoselective process that converts sulfinic acid into stable cyclic sulfonamide analogues (see scheme). This ligation proceeds rapidly under aqueous conditions in high yield, and lays the groundwork for the development of sulfinic acid detection methods in biological systems. Copyright

1,3-dipolar cycloaddition-decarboxylation reactions of an azomethine ylide with isatoic anhydrides: Formation of novel benzodiazepinones

A nonstabilized azomethine ylide reacts with a wide range of substituted isatoic anhydrides to afford novel 1,3-benzodiazepin-5-one derivatives, which are generally isolated in high yield. The transformations involve 1,3-dipolar cycloaddition reactions of the ylide with the anhydrides to give transient, and in a representative case spectroscopically observable, oxazolidine intermediates that undergo ring-opening-decarboxylation-ringclosing reaction cascades to yield the 1,3-benzodiazepin-5-one products.

Antitumor imidazotetrazines. 32. Synthesis of novel imidazotetrazinones and related bicyclic heterocycles to probe the mode of action of the antitumor drug temozolomide

A series of new imidazo[5,1-d]-1,2,3,5-tetrazinones with additional hydrogen-bonding or ionic substituents at the 8-carboxamide position of the antitumor drugs temozolomide (1) and mitozolomide (2) has been prepared. None of these compounds were significantly more cytotoxic in vitro against the mouse TLX5 lymphoma than the lead structures. Molecular modeling techniques have been used to design benzo- and pyrazolo[4,3-d]-1,2,3-triazinones bearing carboxamide groups in appropriate positions which are isosteric with temozolomide and mitozolomide but which cannot ring open to alkylating species. As predicted, these compounds have no inhibitory properties against human GM892A or Raji cell lines in vitro. Temozolomide and the spermidine- temozolomide conjugate 28 preferentially methylate guanines within guanine- rich sequences in DNA, but no experimental evidence has been found to support the hypothesis that such regions are involved in catalyzing the ring opening of the imidazotetrazinone prodrugs to their active forms.