(E)-2-[(Z)-2-Amino-1-(diethoxy-phosphoryl)-2-p-tolyl-vinyl]-but-2-enedioic acid dimethyl ester

Base Information

Chemical Name:(E)-2-[(Z)-2-Amino-1-(diethoxy-phosphoryl)-2-p-tolyl-vinyl]-but-2-enedioic acid dimethyl ester
CAS No.:171561-44-7
Molecular Formula:C₁₉H₂₆NO₇P
Molecular Weight:411.392
Hs Code.:

Synonyms:(E)-2-[(Z)-2-Amino-1-(diethoxy-phosphoryl)-2-p-tolyl-vinyl]-but-2-enedioic acid dimethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-2-[(Z)-2-Amino-1-(diethoxy-phosphoryl)-2-p-tolyl-vinyl]-but-2-enedioic acid dimethyl ester

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Technology Process of (E)-2-[(Z)-2-Amino-1-(diethoxy-phosphoryl)-2-p-tolyl-vinyl]-but-2-enedioic acid dimethyl ester

There total 2 articles about (E)-2-[(Z)-2-Amino-1-(diethoxy-phosphoryl)-2-p-tolyl-vinyl]-but-2-enedioic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 762-42-5
dimethyl acetylenedicarboxylate

: 171561-38-9
2-diethoxyphosphoryl 1-p-tolylethenylamine

: 171561-44-7
(E)-2-[(Z)-2-Amino-1-(diethoxy-phosphoryl)-2-p-tolyl-vinyl]-but-2-enedioic acid dimethyl ester

Guidance literature:: In tetrahydrofuran; for 24h; Ambient temperature;
DOI:10.3987/COM-95-7147

Reference yield:

: 683-08-9
Diethyl methylphosphonate

: 171561-44-7
(E)-2-[(Z)-2-Amino-1-(diethoxy-phosphoryl)-2-p-tolyl-vinyl]-but-2-enedioic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) THF, -78 deg C, 1 h, 2.) THF, 18 h

2: 80 percent / tetrahydrofuran / 24 h / Ambient temperature

With lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.3987/COM-95-7147