Ethyl 6-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]-phenyl}acetyl]amino}-2-methylhexanoate

Base Information

Chemical Name:Ethyl 6-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]-phenyl}acetyl]amino}-2-methylhexanoate
CAS No.:1242456-81-0
Molecular Formula:C₃₂H₄₁N₃O₅
Molecular Weight:547.695
Hs Code.:

Synonyms:Ethyl 6-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]-phenyl}acetyl]amino}-2-methylhexanoate

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Chemical Property of Ethyl 6-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]-phenyl}acetyl]amino}-2-methylhexanoate

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Technology Process of Ethyl 6-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]-phenyl}acetyl]amino}-2-methylhexanoate

There total 9 articles about Ethyl 6-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]-phenyl}acetyl]amino}-2-methylhexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.9%

: 1242456-48-9
ethyl 6-amino-2-methylhexanoate

: (+)-cyclopentyl{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]phenyl}acetic acid

: 1242456-81-0
Ethyl 6-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]-phenyl}acetyl]amino}-2-methylhexanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 16h;

Reference yield:

: 65374-10-9
ethyl 6-azidohexanoate

: 1242456-81-0
Ethyl 6-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]-phenyl}acetyl]amino}-2-methylhexanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.33 h / -78 - -20 °C

1.2: 2 h / -20 - 20 °C

2.1: hydrogen / palladium on activated charcoal / 760.05 Torr

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

With n-butyllithium; hydrogen; diisopropylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium on activated charcoal; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;

Reference yield:

: 25542-62-5
6-bromo-hexanoic acid ethyl ester

: 1242456-81-0
Ethyl 6-{[2-cyclopentyl-2-{4-[(5-oxo-2-phenyl-5,6-dihydro-4H-1,3,4-oxadiazin-4-yl)methyl]-phenyl}acetyl]amino}-2-methylhexanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium azide / N,N-dimethyl-formamide / 20 - 80 °C

2.1: diisopropylamine; n-butyllithium / hexane; tetrahydrofuran / 0.33 h / -78 - -20 °C

2.2: 2 h / -20 - 20 °C

3.1: hydrogen / palladium on activated charcoal / 760.05 Torr

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 0 - 20 °C

With n-butyllithium; sodium azide; hydrogen; diisopropylamine; N-ethyl-N,N-diisopropylamine; HATU; palladium on activated charcoal; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;