9-<3',5'-Bis-O-(2,4-dichlorobenzyl)-β-D-ribofuranosyl>-6-methoxy-9H-purin

Base Information

Chemical Name:9-<3',5'-Bis-O-(2,4-dichlorobenzyl)-β-D-ribofuranosyl>-6-methoxy-9H-purin
CAS No.:168427-71-2
Molecular Formula:C₂₅H₂₂Cl₄N₄O₅
Molecular Weight:600.285
Hs Code.:

Synonyms:9-<3',5'-Bis-O-(2,4-dichlorobenzyl)-β-D-ribofuranosyl>-6-methoxy-9H-purin

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 9-<3',5'-Bis-O-(2,4-dichlorobenzyl)-β-D-ribofuranosyl>-6-methoxy-9H-purin

Chemical Property:

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Technology Process of 9-<3',5'-Bis-O-(2,4-dichlorobenzyl)-β-D-ribofuranosyl>-6-methoxy-9H-purin

There total 7 articles about 9-<3',5'-Bis-O-(2,4-dichlorobenzyl)-β-D-ribofuranosyl>-6-methoxy-9H-purin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 124-41-4
sodium methylate

: 168427-70-1
9-<2'-O-Acetyl-3',5'-bis-O-(2,4-dichlorobenzyl)-β-D-ribofuranosyl>-6-chloro-9H-purin

: 168427-71-2
9-<3',5'-Bis-O-(2,4-dichlorobenzyl)-β-D-ribofuranosyl>-6-methoxy-9H-purin

Guidance literature:: In tetrahydrofuran; methanol; for 3h; Ambient temperature;
DOI:10.1002/hlca.19950780219

Reference yield:

: 50-69-1
D-ribose

: 168427-71-2
9-<3',5'-Bis-O-(2,4-dichlorobenzyl)-β-D-ribofuranosyl>-6-methoxy-9H-purin

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) cc. H₂SO₄, 2.) NaH / 1.) 4 deg C, 16 h, 2.) DMF, 40 deg C

2: 125.9 g / SnCl₄ / CH₂Cl₂ / 35 h / 3 °C

3: pyridine, 4-(dimethylamino)-pyridine / 17 h

4: 63 percent / BSA, TfOSiMe₃ / 1,2-dichloro-ethane / 7 h / 70 °C

5: 96 percent / SOCl₂ / dimethylformamide; CH₂Cl₂ / 5.5 h / 55 °C

6: 90 percent / tetrahydrofuran; methanol / 3 h / Ambient temperature

With pyridine; benzenesulfonamide; dmap; thionyl chloride; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; tin(IV) chloride; sodium hydride; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19950780219

Reference yield:

: 94-99-5
2,4-Dichlorobenzyl chloride

: 168427-71-2
9-<3',5'-Bis-O-(2,4-dichlorobenzyl)-β-D-ribofuranosyl>-6-methoxy-9H-purin

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) cc. H₂SO₄, 2.) NaH / 1.) 4 deg C, 16 h, 2.) DMF, 40 deg C

2: 125.9 g / SnCl₄ / CH₂Cl₂ / 35 h / 3 °C

3: pyridine, 4-(dimethylamino)-pyridine / 17 h

4: 63 percent / BSA, TfOSiMe₃ / 1,2-dichloro-ethane / 7 h / 70 °C

5: 96 percent / SOCl₂ / dimethylformamide; CH₂Cl₂ / 5.5 h / 55 °C

6: 90 percent / tetrahydrofuran; methanol / 3 h / Ambient temperature

With pyridine; benzenesulfonamide; dmap; thionyl chloride; trimethylsilyl trifluoromethanesulfonate; sulfuric acid; tin(IV) chloride; sodium hydride; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19950780219