3-Pyridinamine,2-methoxy-5-methyl-(9CI)

Base Information

• Chemical Name: 3-Pyridinamine,2-methoxy-5-methyl-(9CI)
• CAS No.: 179677-17-9
• Molecular Formula: C7H10 N2 O
• Molecular Weight: 138.17
• Hs Code.: 2933399990
• Mol file: 179677-17-9.mol

Synonyms:3-Amino-2-methoxy-5-methylpyridine

Chemical Property of 3-Pyridinamine,2-methoxy-5-methyl-(9CI)

Chemical Property:

• PSA: 48.14000
• LogP: 1.56200

Purity/Quality:

98%min ^*data from raw suppliers

2-methoxy-5-methylpyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinamine,2-methoxy-5-methyl-(9CI)

There total 4 articles about 3-Pyridinamine,2-methoxy-5-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-methoxy-5-methyl-3-nitropyridine (33252-62-9) → 2-methoxy-5-methylpyridin-3-ylamine (179677-17-9)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 5h;

DOI:10.1021/acs.jmedchem.9b00533

Reference yield: 98.0%

→ 2-methoxy-5-methylpyridin-3-ylamine (179677-17-9)

Guidance literature:

Reference yield:

2-chloro-5-methyl-3-nitro-pyridine (23056-40-8) → 2-methoxy-5-methylpyridin-3-ylamine (179677-17-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / sodium methoxide / 6 h / Heating

2: 90 percent / H₂ / 10percent Pd/C / ethanol

With hydrogen; sodium methylate; palladium on activated charcoal; In ethanol;

DOI:10.1016/0022-328X(95)05979-Y

upstream raw materials:

2-methoxy-5-methyl-3-nitropyridine

2-chloro-5-methyl-3-nitro-pyridine

5-methyl-3-nitropyridin-2(1H)-one

Downstream raw materials:

N-(4-Iodo-5-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-2,2-dimethyl-propionamide

1-(2-methoxy-5-methylpyridin-3-yl)-3-[3-methyl-4-(2-methylpyridin-4-yloxy)-benzyl]-urea