33252-62-9

Usage

Uses

Used in Pharmaceutical Industry:
2-Methoxy-3-Nitro-5-Picoline is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to facilitate the creation of complex molecular structures that can exhibit therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Methoxy-3-Nitro-5-Picoline serves as an essential building block in the development of compounds that can protect crops from pests and diseases, leveraging its reactivity to form agrochemicals with desired properties.
Used in Organic Synthesis:
2-Methoxy-3-Nitro-5-Picoline is utilized as a versatile intermediate in organic synthesis, contributing to the formation of a wide array of organic compounds for various applications, including but not limited to materials science, dyes, and specialty chemicals.
Used in Medicinal Chemistry Research:
2-Methoxy-3-Nitro-5-Picoline is also used as a target in medicinal chemistry research due to its potential biological activities, which can be harnessed to develop new drugs and therapies for various medical conditions.

InChI:InChI=1/C7H8N2O3/c1-5-3-6(9(10)11)7(12-2)8-4-5/h3-4H,1-2H3

Upstream product

• 67-56-1 methanol 
• 23056-40-8 2-chloro-5-methyl-3-nitro-pyridine 
• 124-41-4 sodium methylate 
• 7464-14-4 5-methyl-3-nitropyridin-2(1H)-one 

Downstream Products

• 179677-17-9 2-methoxy-5-methylpyridin-3-ylamine 
• 1353547-72-4 (E)-2-methoxy-3-nitro-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridine 
• 1353547-73-5 (E)-2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-amine 
• 1353547-74-6 (E)-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)acetamide 
• 1353547-75-7 (E)-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)methanesulfonamide 
• 1353547-76-8 (E)-ethyl 2-((2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)amino)acetate 
• 1353547-77-9 (E)-2-((2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)amino)acetic acid 
• 1353547-78-0 (E)-N-ethyl-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)acetamide 
• 1353547-79-1 (E)-2-((2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)amino)acetamide 
• 1353547-80-4 (E)-5-((2,6-dimethoxystyrylsulfonyl)methyl)-2-methoxy-3-nitropyridine 
• 1353547-82-6 (E)-2-methoxy-3-nitro-5-((2,4,6-trimethoxystyrylsulfinyl)methyl)pyridine 
• 1574636-08-0 2-methoxy-5-(1-(methylsulfonyl)-2-(piperidin-1-yl)-2-(2,4,6-trimethoxyphenyl)ethyl)-3-nitropyridine 
• 1574636-32-0 (E)-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)propane-1-sulfonamide 
• 1574636-27-3 (E)-N-(2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)pyridin-3-yl)ethanesulfonamide 

Relevant academic research and scientific papers

TYK2 INHIBITORS AND USES THEREOF

Described herein are compounds that are useful in treating a TYK2-mediated disorder. In some embodiments, the TYK2-mediated disorder is an autoimmune disorder, an inflammatory disorder, a proliferative disorder, an endocrine disorder, a neurological disorder, or a disorder associated with transplantation.

Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases

Janus kinases (JAKs) have a key role in regulating the expression and function of relevant inflammatory cytokines involved in asthma and chronic obstructive pulmonary disease. Herein are described the design, synthesis, and pharmacological evaluation of a series of novel purinone JAK inhibitors with profiles suitable for inhaled administration. Replacement of the imidazopyridine hinge binding motif present in the initial compounds of this series with a pyridone ring resulted in the mitigation of cell cytotoxicity. Further systematic structure-activity relationship (SAR) efforts driven by structural biology studies led to the discovery of pyridone 34, a potent pan-JAK inhibitor with good selectivity, long lung retention time, low oral bioavailability, and proven efficacy in the lipopolysaccharide-induced rat model of airway inflammation by the inhaled route.

Discovery of (E)-3-((styrylsulfonyl)methyl)pyridine and (E)-2-((styrylsulfonyl)methyl)pyridine derivatives as anticancer agents: Synthesis, structure-activity relationships, and biological activities

ON01910.Na is a highly effective anticancer agent that induces mitotic arrest and apoptosis. Clinical studies with ON01910 in cancer patients have shown efficacy along with an impressive safety profile. While ON01910 is highly active against cancer cells,

Pyridin-2(1H)-one derivatives useful as medicaments for the treatment of myeloproliferative disorders, transplant rejection, immune-mediated and inflammatory diseases

New pyridin-2(1h)-one derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

PYRIDIN-2 (1H) -ONE DERIVATIVES USEFUL AS MEDICAMENTS FOR THE TREATMENT OF MYELOPROLIFERATIVE DISORDERS, TRANSPLANT REJECTION, IMMUNE-MEDIATED AND INFLAMMATORY DISEASES

Compoundshaving the chemical structure of formula (I) are disclosed; as well as process for theirpreparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).

COMPOUNDS FOR TREATING PROLIFERATIVE DISORDERS

.A compound of formula (I) or a pharmaceutically acceptable salt or solvate or physiologically hydrolysable, solubilising or immobilisable derivative thereof; wherein: any one or two of X·,, X2 and X3 is a N atom and the remaining two or one of X1, X2 and

Metallation in connection with cross-coupling reactions. Coupling of hindered aryls for the synthesis of 4-phenylpyridines as part of Streptonigrin and Lavendamycin analogues

The synthesis of the C-D ring system of Streptonigrin and Lavendamycln alkaloid analogues by cross-coupling under Suzuki's conditions has been studied. Steric hindrance is the main problem. It has been solved either by using strong bases or working in a sealed tube under pressure.