Toluene-4-sulfonic acid 7-[(R)-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-2-methyl-3-phenyl-propionylamino]-heptyl ester

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Chemical Name:Toluene-4-sulfonic acid 7-[(R)-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-2-methyl-3-phenyl-propionylamino]-heptyl ester
CAS No.:173436-08-3
Molecular Formula:C₃₈H₅₁N₃O₇S
Molecular Weight:693.905
Hs Code.:

Synonyms:Toluene-4-sulfonic acid 7-[(R)-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-2-methyl-3-phenyl-propionylamino]-heptyl ester

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Chemical Property of Toluene-4-sulfonic acid 7-[(R)-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-2-methyl-3-phenyl-propionylamino]-heptyl ester

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Technology Process of Toluene-4-sulfonic acid 7-[(R)-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-2-methyl-3-phenyl-propionylamino]-heptyl ester

There total 4 articles about Toluene-4-sulfonic acid 7-[(R)-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-2-methyl-3-phenyl-propionylamino]-heptyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19243-04-0
7-amino-1-heptanol

: 173436-08-3
Toluene-4-sulfonic acid 7-[(R)-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-2-methyl-3-phenyl-propionylamino]-heptyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: DCCI, HOBt, DIPEA / dimethylformamide / 15 h

2: 359 mg / Et₃N, DMAP / CH₂Cl₂ / 15 h

With dmap; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm950892r

Reference yield:

: 60142-89-4
7-[(tert-butoxycarbonyl)amino]heptanoic acid

: 173436-08-3
Toluene-4-sulfonic acid 7-[(R)-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-2-methyl-3-phenyl-propionylamino]-heptyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) N-methylmorpholine, ethyl chloroformate, 2.) LiBH₄ / 1.) THF, 0 deg C, 1 h, 2.) THF, from 0 deg C to RT, 3 h

2: TFA / CH₂Cl₂ / 1 h

3: DCCI, HOBt, DIPEA / dimethylformamide / 15 h

4: 359 mg / Et₃N, DMAP / CH₂Cl₂ / 15 h

With 4-methyl-morpholine; dmap; lithium borohydride; chloroformic acid ethyl ester; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm950892r

Reference yield:

: 173436-02-7
(7-hydroxyheptyl)carbamic acid tert-butyl ester

: 173436-08-3
Toluene-4-sulfonic acid 7-[(R)-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-2-methyl-3-phenyl-propionylamino]-heptyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: TFA / CH₂Cl₂ / 1 h

2: DCCI, HOBt, DIPEA / dimethylformamide / 15 h

3: 359 mg / Et₃N, DMAP / CH₂Cl₂ / 15 h

With dmap; benzotriazol-1-ol; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm950892r