(7-Hydroxy-heptyl)-carbamic acid tert-butyl ester

Base Information

• Chemical Name: (7-Hydroxy-heptyl)-carbamic acid tert-butyl ester
• CAS No.: 173436-02-7
• Molecular Formula: C₁₂H₂₅NO₃
• Molecular Weight: 231.335
• European Community (EC) Number: 889-217-7
• Mol file: 173436-02-7.mol

Synonyms:173436-02-7;tert-Butyl (7-hydroxyheptyl)carbamate;Tert-butyl N-(7-hydroxyheptyl)carbamate;(7-Hydroxy-heptyl)-carbamic acid tert-butyl ester;Boc-7-aminoheptan-1-ol;7-(Boc-amino)-1-heptanol;SCHEMBL15508929;MFCD02094527;AT22496;BS-34960;SY299923;CS-0160058;(7-Hydroxyheptyl)carbamic acid tert-butyl ester;EN300-181797;A1-02857

Chemical Property of (7-Hydroxy-heptyl)-carbamic acid tert-butyl ester

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 9
• Exact Mass: 231.18344366
• Heavy Atom Count: 16
• Complexity: 187

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)NCCCCCCCO

Technology Process of (7-Hydroxy-heptyl)-carbamic acid tert-butyl ester

There total 9 articles about (7-Hydroxy-heptyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

7-amino-1-heptanol (19243-04-0) + di-tert-butyl dicarbonate (24424-99-5) → (7-hydroxyheptyl)carbamic acid tert-butyl ester (173436-02-7)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

DOI:10.1002/anie.201202090

Reference yield: 67.0%

di-tert-butyl dicarbonate (24424-99-5) + 7-azido-heptan-1-ol (57395-45-6) → (7-hydroxyheptyl)carbamic acid tert-butyl ester (173436-02-7)

Guidance literature:

With palladium on activated carbon; hydrogen; In ethyl acetate; at 25 ℃; for 16h; under 2585.81 Torr;

Reference yield: 53.0%

carbon monoxide (201230-82-2) + 6-((tert-butoxycarbonyl)amino)hexyl 4-methylbenzenesulfonate (86536-92-7) → (7-hydroxyheptyl)carbamic acid tert-butyl ester (173436-02-7)

Guidance literature:

With sodium tetrahydroborate; dimanganese decacarbonyl; In 1,4-dioxane; tert-Amyl alcohol; at 50 ℃; for 18h; under 7600.51 Torr; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.9b03706

upstream raw materials:

7-[(tert-butoxycarbonyl)amino]heptanoic acid

7-bromoheptyl alcohol

1,7-heptandiol

7-amino-1-heptanol

Downstream raw materials:

(S)-2-Benzyloxycarbonylamino-3-[4-(7-tert-butoxycarbonylamino-heptyloxy)-phenyl]-propionic acid

{(S)-1-[(R)-1-(7-Hydroxy-heptylcarbamoyl)-1-methyl-2-phenyl-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Toluene-4-sulfonic acid 7-[(R)-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-2-methyl-3-phenyl-propionylamino]-heptyl ester

{(S)-1-[(R)-1-(7-Azido-heptylcarbamoyl)-1-methyl-2-phenyl-ethylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester

Refernces

• 1、 Connon, Stephen J.,Ghanim, Magda,Kelly, Vincent P.,McDonnell, Ciara M.,Mike Southern, J.. "De-novo designed β-lysine derivatives can both augment and diminish the proliferation rates of E. coli through the action of Elongation Factor P". supporting information. . Retrieved 2022/01/24.
• 2、 -. "IRAK DEGRADERS AND USES THEREOF". . . Retrieved 2020/06/19.