3-({4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzyl}amino)propanoic acid

Base Information

Chemical Name:3-({4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzyl}amino)propanoic acid
CAS No.:1379928-80-9
Molecular Formula:C₂₈H₃₀FNO₂
Molecular Weight:431.55
Hs Code.:

Synonyms:3-({4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzyl}amino)propanoic acid

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Chemical Property of 3-({4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzyl}amino)propanoic acid

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Technology Process of 3-({4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzyl}amino)propanoic acid

There total 5 articles about 3-({4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzyl}amino)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1379649-46-3
4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzaldehyde

: 107-95-9
3-amino propanoic acid

: 1379928-80-9
3-({4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzyl}amino)propanoic acid

Guidance literature:: 4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzaldehyde; 3-amino propanoic acid; With acetic acid; In methanol; at 20 ℃; for 0.333333h;

With sodium cyanoborohydride; In methanol; at 20 ℃; for 2h;

Reference yield:

: 1379649-41-8
3-(3,4-dimethylphenyl)-2-(3-fluorophenyl)propanal

: 1379928-80-9
3-({4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzyl}amino)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C

1.2: 2 h / 0 °C

2.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

2.2: -20 °C / Celite

3.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane; acetonitrile / 2 h / 20 °C / Molecular sieve

4.1: acetic acid / methanol / 0.33 h / 20 °C

4.2: 2 h / 20 °C

With tetrapropylammonium perruthennate; sodium hydride; diisobutylaluminium hydride; acetic acid; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 1379649-45-2
methyl 4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzoate

: 1379928-80-9
3-({4-[(1E)-4-(3,4-dimethylphenyl)-3-(3-fluorophenyl)but-1-en-1-yl]benzyl}amino)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 3 h / -78 °C / Inert atmosphere

1.2: -20 °C / Celite

2.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane; acetonitrile / 2 h / 20 °C / Molecular sieve

3.1: acetic acid / methanol / 0.33 h / 20 °C

3.2: 2 h / 20 °C

With tetrapropylammonium perruthennate; diisobutylaluminium hydride; acetic acid; 4-methylmorpholine N-oxide; In tetrahydrofuran; methanol; dichloromethane; toluene; acetonitrile;