N-Benzyloxy-N'-[(S)-1-(carbamoylmethyl-carbamoyl)-ethyl]-2-isobutyl-malonamide

Base Information

Chemical Name:N-Benzyloxy-N'-[(S)-1-(carbamoylmethyl-carbamoyl)-ethyl]-2-isobutyl-malonamide
CAS No.:71431-58-8
Molecular Formula:C₁₉H₂₈N₄O₅
Molecular Weight:392.455
Hs Code.:

Synonyms:N-Benzyloxy-N'-[(S)-1-(carbamoylmethyl-carbamoyl)-ethyl]-2-isobutyl-malonamide

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Chemical Property of N-Benzyloxy-N'-[(S)-1-(carbamoylmethyl-carbamoyl)-ethyl]-2-isobutyl-malonamide

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Technology Process of N-Benzyloxy-N'-[(S)-1-(carbamoylmethyl-carbamoyl)-ethyl]-2-isobutyl-malonamide

There total 4 articles about N-Benzyloxy-N'-[(S)-1-(carbamoylmethyl-carbamoyl)-ethyl]-2-isobutyl-malonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87438-95-7
2-Benzyloxycarbamoyl-4-methyl-pentanoic acid

: (DL)-alanylglycineamide

: 71431-58-8
N-Benzyloxy-N'-[(S)-1-(carbamoylmethyl-carbamoyl)-ethyl]-2-isobutyl-malonamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 0 - 20 ℃; for 12h;
DOI:10.1021/jm9706426

Reference yield:

: 2687-43-6
O-benzylhydoxylamine hydrochloride

: 71431-58-8
N-Benzyloxy-N'-[(S)-1-(carbamoylmethyl-carbamoyl)-ethyl]-2-isobutyl-malonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) MeONa, 2.) EDCl, HOBt / 1.) THF, 10 min, 2.) THF, RT, 12 h

2: 85 percent / aq. NaOH / tetrahydrofuran; methanol / 1 h / 50 °C

3: HOBt, EDCl / tetrahydrofuran / 12 h / 0 - 20 °C

With sodium hydroxide; sodium methylate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol;
DOI:10.1021/jm9706426

Reference yield:

: 179901-13-4
2-Benzyloxycarbamoyl-4-methylpentanoic acid ethyl ester

: 71431-58-8
N-Benzyloxy-N'-[(S)-1-(carbamoylmethyl-carbamoyl)-ethyl]-2-isobutyl-malonamide

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / aq. NaOH / tetrahydrofuran; methanol / 1 h / 50 °C

2: HOBt, EDCl / tetrahydrofuran / 12 h / 0 - 20 °C

With sodium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol;
DOI:10.1021/jm9706426