DBCO-PEG4-amine

Base Information

Chemical Name:DBCO-PEG4-amine
CAS No.:1255942-08-5
Molecular Formula:C₂₉H₃₇N₃O₆
Molecular Weight:523.629
Hs Code.:
Mol file:1255942-08-5.mol

Synonyms:DBCO-PEG₄-amine

Suppliers and Price of DBCO-PEG4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
DBCO-PEG4-amine
1mg
$ 160.00

TRC
DBCO-PEG4-amine
2.5mg
$ 345.00

purepeg
DBCO-NH-PEG4-CH2CH2NH2 min.95%
100 mg
$ 450.00

Iris Biotech GmbH
DBCO-PEG(4)-NH2
500 mg
$ 2700.00

Chem-Impex
DBCO-PEG-amine ≥ 95% (HPLC)
25MG
$ 180.00

Chem-Impex
DBCO-PEG-amine ≥ 95% (HPLC)
5MG
$ 50.00

Chem-Impex
DBCO-PEG-amine ≥ 95% (HPLC)
100MG
$ 470.00

Chem-Impex
DBCO-PEG4-amineTFASalt,99%(HPLC) 99%(HPLC)
250MG
$ 1106.56

BroadPharm
DBCO-NHCO-PEG4-amineTFAsalt 98%
1 G
$ 2540.00

BroadPharm
DBCO-NHCO-PEG4-amineTFAsalt 98%
500 MG
$ 1695.00

Total 26 raw suppliers

Chemical Property of DBCO-PEG4-amine

Chemical Property:

Boiling Point:784.1±60.0 °C(Predicted)
PKA:15.14±0.46(Predicted)
Density:1.23±0.1 g/cm3(Predicted)
Storage Temp.:-20°C Freezer, Under inert atmosphere
Solubility.:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Water Solubility.:Soluble in water.

Purity/Quality:

98%,99%, ^*data from raw suppliers

DBCO-PEG4-amine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description DBCO-NHCO-PEG4-amine is a carboxyl-reactive building block with extended PEG spacer arm. The hydrophilic PEG spacer arm improves water solubility. In the presence of of activators (e.g. EDC, or HATU), this reagent can be used to derivatize carboxyl groups or activated esters (e.g. The NHS ester) through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions.

Technology Process of DBCO-PEG4-amine

There total 9 articles about DBCO-PEG4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1255942-12-1
N-boc protected ADIBO-PEG₄-amine

: 1255942-08-5
DBCO-PEG₄-amine

Guidance literature:: With trifluoroacetic acid; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/bc100306u

Reference yield:

: 1255942-06-3
N-(3-aminopropionyl)-5,6-dihydro-11,12-didehydrodibenzo[b,f]azocine

: 1255942-08-5
DBCO-PEG₄-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

1.2: 4 h / 20 °C

2.1: trifluoroacetic acid / tetrahydrofuran / 20 °C

With 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/bc100306u

Reference yield:

: C₂₀H₁₇F₃N₂O₂

: 1255942-08-5
DBCO-PEG₄-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridinium perbromide hydrobromide / dichloromethane / 20 °C

2.1: potassium tert-butylate / tetrahydrofuran / 1 h / 20 °C

3.1: potassium carbonate / methanol; water / 20 °C

4.1: 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.25 h / 20 °C

4.2: 4 h / 20 °C

5.1: trifluoroacetic acid / tetrahydrofuran / 20 °C

With pyridinium perbromide hydrobromide; potassium tert-butylate; potassium carbonate; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/bc100306u