(2R,4R)-6-chloro-4-methyl-3-[(4-methylphenyl)sulfonyl]-2-(2,6-dimethoxy)phenyl-3,4-dihydro-2H-1,3,2-benzoxazaphosphinine 2-oxide

Base Information

Chemical Name:(2R,4R)-6-chloro-4-methyl-3-[(4-methylphenyl)sulfonyl]-2-(2,6-dimethoxy)phenyl-3,4-dihydro-2H-1,3,2-benzoxazaphosphinine 2-oxide
CAS No.:1421840-56-3
Molecular Formula:C₂₃H₂₃ClNO₆PS
Molecular Weight:507.931
Hs Code.:

Synonyms:(2R,4R)-6-chloro-4-methyl-3-[(4-methylphenyl)sulfonyl]-2-(2,6-dimethoxy)phenyl-3,4-dihydro-2H-1,3,2-benzoxazaphosphinine 2-oxide

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Chemical Property of (2R,4R)-6-chloro-4-methyl-3-[(4-methylphenyl)sulfonyl]-2-(2,6-dimethoxy)phenyl-3,4-dihydro-2H-1,3,2-benzoxazaphosphinine 2-oxide

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Technology Process of (2R,4R)-6-chloro-4-methyl-3-[(4-methylphenyl)sulfonyl]-2-(2,6-dimethoxy)phenyl-3,4-dihydro-2H-1,3,2-benzoxazaphosphinine 2-oxide

There total 8 articles about (2R,4R)-6-chloro-4-methyl-3-[(4-methylphenyl)sulfonyl]-2-(2,6-dimethoxy)phenyl-3,4-dihydro-2H-1,3,2-benzoxazaphosphinine 2-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1421840-44-9
(R)-N-(1-(5-chloro-2-hydroxyphenyl)ethyl)-4-methylbenzenesulfonamide

: C₈H₉Cl₂O₃P

: 1421840-56-3
(2R,4R)-6-chloro-4-methyl-3-[(4-methylphenyl)sulfonyl]-2-(2,6-dimethoxy)phenyl-3,4-dihydro-2H-1,3,2-benzoxazaphosphinine 2-oxide

Guidance literature:: With pyridine; In dichloromethane; at -20 - 20 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 1421840-44-9
(R)-N-(1-(5-chloro-2-hydroxyphenyl)ethyl)-4-methylbenzenesulfonamide

: 137600-71-6
2,5-(dimethoxyphenyl)magnesium bromide

: 1421840-56-3
(2R,4R)-6-chloro-4-methyl-3-[(4-methylphenyl)sulfonyl]-2-(2,6-dimethoxy)phenyl-3,4-dihydro-2H-1,3,2-benzoxazaphosphinine 2-oxide

Guidance literature:: (R)-N-(1-(5-chloro-2-hydroxyphenyl)ethyl)-4-methylbenzenesulfonamide; With 1-methyl-1H-imidazole; phosphorus trichloride; In tetrahydrofuran; at -70 - -10 ℃; for 1h; Inert atmosphere;

2,5-(dimethoxyphenyl)magnesium bromide; In tetrahydrofuran; at -70 - -10 ℃; Inert atmosphere;

With dihydrogen peroxide; at 5 ℃; Inert atmosphere;
DOI:10.1002/anie.201500350

Reference yield:

: 1228571-53-6
(R)-2-(1-aminoethyl)-4-chlorophenol

: 1421840-56-3
(2R,4R)-6-chloro-4-methyl-3-[(4-methylphenyl)sulfonyl]-2-(2,6-dimethoxy)phenyl-3,4-dihydro-2H-1,3,2-benzoxazaphosphinine 2-oxide

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethyl acetate / 20 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: lithium hydroxide / 60 °C / Inert atmosphere

3.2: 20 °C / pH 4 / Inert atmosphere

4.1: pyridine / dichloromethane / -15 - 20 °C / Inert atmosphere

5.1: hydrogenchloride; dihydrogen peroxide / water / 1 h / Inert atmosphere

With pyridine; hydrogenchloride; dihydrogen peroxide; sodium hydride; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; ethyl acetate;
DOI:10.1021/ja312352p