ethyl N-[(3-{[N'-(4-chloro-3-methyl-5-isoxazolyl)-N'-(methoxymethyl)amino]sulfonyl}-2-thienyl)carbonyl]-N-(3-acetoxy-2,4,6-trimethylphenyl)carbamate

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Chemical Name:ethyl N-[(3-{[N'-(4-chloro-3-methyl-5-isoxazolyl)-N'-(methoxymethyl)amino]sulfonyl}-2-thienyl)carbonyl]-N-(3-acetoxy-2,4,6-trimethylphenyl)carbamate
CAS No.:250651-13-9
Molecular Formula:C₂₅H₂₈ClN₃O₉S₂
Molecular Weight:614.097
Hs Code.:

Synonyms:ethyl N-[(3-{[N'-(4-chloro-3-methyl-5-isoxazolyl)-N'-(methoxymethyl)amino]sulfonyl}-2-thienyl)carbonyl]-N-(3-acetoxy-2,4,6-trimethylphenyl)carbamate

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Chemical Property of ethyl N-[(3-{[N'-(4-chloro-3-methyl-5-isoxazolyl)-N'-(methoxymethyl)amino]sulfonyl}-2-thienyl)carbonyl]-N-(3-acetoxy-2,4,6-trimethylphenyl)carbamate

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Technology Process of ethyl N-[(3-{[N'-(4-chloro-3-methyl-5-isoxazolyl)-N'-(methoxymethyl)amino]sulfonyl}-2-thienyl)carbonyl]-N-(3-acetoxy-2,4,6-trimethylphenyl)carbamate

There total 9 articles about ethyl N-[(3-{[N'-(4-chloro-3-methyl-5-isoxazolyl)-N'-(methoxymethyl)amino]sulfonyl}-2-thienyl)carbonyl]-N-(3-acetoxy-2,4,6-trimethylphenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 541-41-3
chloroformic acid ethyl ester

: 250651-12-8
acetic acid 3-({3-[(4-chloro-3-methyl-isoxazol-5-yl)-methoxymethyl-sulfamoyl]-thiophene-2-carbonyl}-amino)-2,4,6-trimethyl-phenyl ester

: 250651-13-9
ethyl N-[(3-{[N'-(4-chloro-3-methyl-5-isoxazolyl)-N'-(methoxymethyl)amino]sulfonyl}-2-thienyl)carbonyl]-N-(3-acetoxy-2,4,6-trimethylphenyl)carbamate

Guidance literature:: acetic acid 3-({3-[(4-chloro-3-methyl-isoxazol-5-yl)-methoxymethyl-sulfamoyl]-thiophene-2-carbonyl}-amino)-2,4,6-trimethyl-phenyl ester; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at 0 ℃; for 0.5h;

chloroformic acid ethyl ester; In tetrahydrofuran; toluene; at 0 - 20 ℃; for 2.25h;
DOI:10.1021/jm9900063

Reference yield:

: 527-60-6
Mesitol

: 250651-13-9
ethyl N-[(3-{[N'-(4-chloro-3-methyl-5-isoxazolyl)-N'-(methoxymethyl)amino]sulfonyl}-2-thienyl)carbonyl]-N-(3-acetoxy-2,4,6-trimethylphenyl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: Et₃N

2.1: 70 percent HNO₃; conc. H₂SO₄; AcOH / 1 h

3.1: Fe; AcOH / 1 h / 90 - 110 °C

4.1: tetrahydrofuran / 20 °C

5.1: potassium bis(trimethylsilyl)amide / tetrahydrofuran; toluene / 0.5 h / 0 °C

5.2: 64 percent / tetrahydrofuran; toluene / 2.25 h / 0 - 20 °C

With sulfuric acid; nitric acid; potassium hexamethylsilazane; iron; acetic acid; triethylamine; In tetrahydrofuran; toluene; 1.1: Acetylation / 2.1: Nitration / 3.1: Reduction / 4.1: Acylation / 5.1: Metallation / 5.2: Acylation;
DOI:10.1021/jm9900063

Reference yield:

: 115231-65-7
acetic acid-(2,4,6-trimethyl-3-nitro-phenyl ester)

: 250651-13-9
ethyl N-[(3-{[N'-(4-chloro-3-methyl-5-isoxazolyl)-N'-(methoxymethyl)amino]sulfonyl}-2-thienyl)carbonyl]-N-(3-acetoxy-2,4,6-trimethylphenyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: Fe; AcOH / 1 h / 90 - 110 °C

2.1: tetrahydrofuran / 20 °C

3.1: potassium bis(trimethylsilyl)amide / tetrahydrofuran; toluene / 0.5 h / 0 °C

3.2: 64 percent / tetrahydrofuran; toluene / 2.25 h / 0 - 20 °C

With potassium hexamethylsilazane; iron; acetic acid; In tetrahydrofuran; toluene; 1.1: Reduction / 2.1: Acylation / 3.1: Metallation / 3.2: Acylation;
DOI:10.1021/jm9900063