3,5-DIFLUOROBENZOPHENONE

Base Information

• Chemical Name: 3,5-DIFLUOROBENZOPHENONE
• CAS No.: 179113-89-4
• Molecular Formula: C13H8 F2 O
• Molecular Weight: 218.203
• Hs Code.: 2914700090
• Mol file: 179113-89-4.mol

Synonyms:3,5-Difluorobenzophenone

Chemical Property of 3,5-DIFLUOROBENZOPHENONE

Chemical Property:

• Vapor Pressure: 0.000616mmHg at 25°C
• Melting Point: 57-59°C
• Refractive Index: 1.549
• Boiling Point: 117°C 5mm
• Flash Point: 118.9°C
• PSA: 17.07000
• Density: 1.239g/cm³
• LogP: 3.19580
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3,5-Difluorobenzophenone ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-DIFLUOROBENZOPHENONE

There total 27 articles about 3,5-DIFLUOROBENZOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

tert-butyl benzoyl(tert-butoxycarbonyl)carbamate (135364-97-5) + 3,5-difluorophenylboronic acid (156545-07-2) → (3,5-difluorophenyl)(phenyl)methanone (179113-89-4)

Guidance literature:

With potassium fluoride; (3-phenylallyl)(chloro)-[1,3-bis(2,6-diisopropylphenyl)-4,5-dihydroimidazol-2-ylidene]palladium(II); In water; toluene; at 23 ℃; for 15h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.7b03191

Reference yield: 90.0%

2-(3,5-difluorophenyl)-2-oxoacetic acid + phenylboronic acid (98-80-6) → (3,5-difluorophenyl)(phenyl)methanone (179113-89-4)

Guidance literature:

With silver carbonate; In acetonitrile; at 60 ℃; for 1h;

DOI:10.1039/c4ra04361h

Reference yield: 89.0%

N-benzoyl saccharin (37952-93-5) + 3,5-difluorophenylboronic acid (156545-07-2) → (3,5-difluorophenyl)(phenyl)methanone (179113-89-4)

Guidance literature:

With boric acid; palladium diacetate; potassium carbonate; dicyclohexylphenylphosphine; In tetrahydrofuran; at 120 ℃; for 15h; Inert atmosphere; Schlenk technique;

DOI:10.1021/acs.orglett.6b01836

upstream raw materials:

3,5-difluorobromobenzene

benzoyl chloride

benzaldehyde

bromobenzene

Downstream raw materials:

3,5-bis-[p-methoxyphenoxy]benzophenone

(3,5-difluorophenyl)diphenylmethanol

3,5-difluoro-α-benzenemethanol

1-(2-(2-bromophenyl)-1-phenylethyl)-3,5-difluorobenzene

Refernces

• 1、 Zhang, Yilan,Yue, Xiaoguang,Liang, Chenfeng,Zhao, Jianming,Yu, Wenbo,Zhang, Pengfei. "Photo-induced oxidative cleavage of C-C double bonds of olefins in water". supporting information. . Retrieved 2021/08/27.
• 2、 Zhou, Tongliang,Li, Guangchen,Nolan, Steven P.,Szostak, Michal. "Well-Defined, Air-Stable, and Readily Available Precatalysts for Suzuki and Buchwald-Hartwig Cross-coupling (Transamidation) of Amides and Esters by N-C/O-C Activation". supporting information. p. 3304 - 3309. Retrieved 2019/05/10.