37952-93-5

Basic information

• Product Name: 1,2-Benzisothiazol-3(2H)-one, 2-benzoyl-, 1,1-dioxide
• CAS NO: 37952-93-5
• Molecular Formula: C14H9NO4S
• Molecular Weight: 287.296
• Mol File: 37952-93-5.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 1,2-Benzisothiazol-3(2H)-one, 2-benzoyl-, 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Benzisothiazol-3(2H)-one, 2-benzoyl-, 1,1-dioxide(37952-93-5)
• EPA Substance Registry System: 1,2-Benzisothiazol-3(2H)-one, 2-benzoyl-, 1,1-dioxide(37952-93-5)

Safety Data

• Hazardous Substances Data: 37952-93-5(Hazardous Substances Data)

Upstream product

• 13947-20-1 N-(hydroxymethyl)saccharin 
• 98-88-4 benzoyl chloride 
• 65-85-0 benzoic acid 
• 81-07-2 saccharin 

Downstream Products

• 100-52-7 benzaldehyde 
• 7338-94-5 1,3-diphenyl-2-propynone 
• 1613380-88-3 3-(4-(propyl)phenyl)-1-phenylpropan-2-yn-1-one 
• 29776-35-0 1-(4-chlorophenyl)-3-phenylprop-2-yn-1-one 
• 20442-66-4 3-(4-methoxyphenyl)-1-phenylprop-2-yn-1-one 
• 1245504-91-9 1-phenyl-3-(thiophene-3-yl)prop-2-yn-1-one 
• 78633-37-1 1,5-diphenyl-2-pentyn-1-one 
• 1083010-55-2 3-cyclopropyl-1-phenylprop-2-yn-1-one 
• 119-61-9 benzophenone 
• 13993-17-4 3-(1H-indol-3-yl)-1-phenylpropan-1-one 
• 712-50-5 Cyclohexyl phenyl ketone 
• 31366-05-9 (±)2-methyl-1-phenylpentan-1-one 
• 942-92-7 caprophenone 
• 24845-40-7 2-(4-methoxyphenyl)acetophenone 

Relevant articles and documents

Water Phase, Room Temperature, Ligand-Free Suzuki–Miyaura Cross-Coupling: A Green Gateway to Aryl Ketones by C–N Bond Cleavage

We report herein a green strategy for synthesis of aryl ketones from twisted amides by using Pd(OAc)2 as catalysts. This method shows high functional group tolerance to offer a variety of ketones in good yields under mild conditions (up to 94 %). Notably, this methodology demonstrates the first water phase, room temperature, ligand-free Suzuki–Miyaura coupling through C–N bond cleavage, which is environmentally friendly and might facilitate the development of amide based green chemistry.

Nickel-Mediated Photoreductive Cross Coupling of Carboxylic Acid Derivatives for Ketone Synthesis**

A simple visible light photochemical, nickel-catalyzed synthesis of ketones from carboxylic acid-derived precursors is presented. Hantzsch ester (HE) functions as a cheap, green and strong photoreductant to facilitate radical generation and also engages in the Ni-catalytic cycle to restore the reactive species. With this dual role, HE allows for the coupling of a large variety of radicals (1°,2°, benzylic, α-oxy & α-amino) with aroyl and alkanoyl moieties, a new feature in reactions of this type. With both precursors deriving from abundant carboxylic acids, this protocol is a welcome addition to the organic chemistry toolbox. The reaction proceeds under mild conditions without the need for toxic metal reagents or bases and shows a wide scope, including pharmaceuticals and complex molecular architectures.

Na2CO3-promoted thioesterification via N–C bond cleavage of amides to construct thioester derivatives

A mild, efficient, and transition-metal-free catalytic strategy is developed to construct thioesters via selective N–C bond cleavage of Boc2-activated primary amides. This strategy is successfully carried out with stoichiometric Na2C