(R)-(3-(4-(5-aminopentyl)-2,5-dichlorobenzyl)thiazolidin-4-yl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone

Base Information

Chemical Name:(R)-(3-(4-(5-aminopentyl)-2,5-dichlorobenzyl)thiazolidin-4-yl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone
CAS No.:1445983-25-4
Molecular Formula:C₂₇H₃₄Cl₂N₄OS
Molecular Weight:533.565
Hs Code.:

Synonyms:(R)-(3-(4-(5-aminopentyl)-2,5-dichlorobenzyl)thiazolidin-4-yl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone

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Chemical Property of (R)-(3-(4-(5-aminopentyl)-2,5-dichlorobenzyl)thiazolidin-4-yl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone

Chemical Property:

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Technology Process of (R)-(3-(4-(5-aminopentyl)-2,5-dichlorobenzyl)thiazolidin-4-yl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone

There total 18 articles about (R)-(3-(4-(5-aminopentyl)-2,5-dichlorobenzyl)thiazolidin-4-yl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1445985-53-4
(R)-tert-butyl 5-(2,5-dichloro-4-((4-(4-cyclopropyl-1,2,3,4-tetrahydroquinoxaline-1-carbonyl)thiazolidin-3-yl)methyl)phenyl)pentylcarbamate

: 1445983-25-4
(R)-(3-(4-(5-aminopentyl)-2,5-dichlorobenzyl)thiazolidin-4-yl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 1h;

Reference yield:

: 381229-74-9
4-methoxy-3,6-dichlorobenzaldehyde

: 1445983-25-4
(R)-(3-(4-(5-aminopentyl)-2,5-dichlorobenzyl)thiazolidin-4-yl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone

Guidance literature:: Multi-step reaction with 8 steps

1: lithium chloride / N,N-dimethyl-formamide / 140 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

3: N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide

4: hydrogen; rhodium contaminated with carbon / ethyl acetate

5: sodium tetrahydroborate / methanol / 1.5 h / 0 °C

6: triphenylphosphine; N-Bromosuccinimide / dichloromethane; tetrahydrofuran / 1 h / 0 - 20 °C

7: potassium carbonate / N,N-dimethyl-formamide

8: hydrogenchloride / water; 1,4-dioxane / 1 h

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; N-Bromosuccinimide; copper(l) iodide; rhodium contaminated with carbon; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium chloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; 3: |Sonogashira Cross-Coupling;
DOI:10.1021/acs.jmedchem.8b00308

Reference yield:

: 27164-10-9
2,5-dichloro-4-hydroxybenzaldehyde

: 1445983-25-4
(R)-(3-(4-(5-aminopentyl)-2,5-dichlorobenzyl)thiazolidin-4-yl)(4-cyclopropyl-3,4-dihydroquinoxalin-1(2H)-yl)methanone

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / N,N-dimethyl-formamide

3: hydrogen; rhodium contaminated with carbon / ethyl acetate

4: sodium tetrahydroborate / methanol / 1.5 h / 0 °C

5: triphenylphosphine; N-Bromosuccinimide / dichloromethane; tetrahydrofuran / 1 h / 0 - 20 °C

6: potassium carbonate / N,N-dimethyl-formamide

7: hydrogenchloride / water; 1,4-dioxane / 1 h

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; N-Bromosuccinimide; copper(l) iodide; rhodium contaminated with carbon; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; 2: |Sonogashira Cross-Coupling;
DOI:10.1021/acs.jmedchem.8b00308