(S)-2-amino-5-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)pent-1-ynyl)pyrimidin-4(1H)-one

Base Information

Chemical Name:(S)-2-amino-5-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)pent-1-ynyl)pyrimidin-4(1H)-one
CAS No.:1380423-93-7
Molecular Formula:C₃₁H₄₃N₃O₃Si₂
Molecular Weight:561.872
Hs Code.:

Synonyms:(S)-2-amino-5-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)pent-1-ynyl)pyrimidin-4(1H)-one

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Chemical Property of (S)-2-amino-5-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)pent-1-ynyl)pyrimidin-4(1H)-one

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Technology Process of (S)-2-amino-5-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)pent-1-ynyl)pyrimidin-4(1H)-one

There total 6 articles about (S)-2-amino-5-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)pent-1-ynyl)pyrimidin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1380423-92-6
(S)-5-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)pent-1-ynyl)-1,3-dimethylpyrimidine-2,4(1H,3H)-dione

: 1380423-93-7
(S)-2-amino-5-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)pent-1-ynyl)pyrimidin-4(1H)-one

Guidance literature:: With guanidine hydrochloride; sodium ethanolate; In ethanol; at 96 ℃; for 1.5h;

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1380423-93-7
(S)-2-amino-5-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)pent-1-ynyl)pyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide

1.2: 0 °C

2.1: n-butyllithium; boron trifluoride diethyl etherate / tetrahydrofuran / -78 °C / Inert atmosphere

3.1: 1H-imidazole / N,N-dimethyl-formamide / Inert atmosphere

3.2: Inert atmosphere

4.1: methanol; sodium methylate / methanol / 1 h / 20 °C / Inert atmosphere

5.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 17 h

6.1: guanidine hydrochloride; sodium ethanolate / ethanol / 1.5 h / 96 °C

With 1H-imidazole; methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; boron trifluoride diethyl etherate; guanidine hydrochloride; sodium methylate; sodium ethanolate; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 895153-57-8
(S)-1-(tert-butyldiphenylsilyloxy)-5-(trimethylsilyl)pent-4-yn-2-ol

: 1380423-93-7
(S)-2-amino-5-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy)pent-1-ynyl)pyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / Inert atmosphere

1.2: Inert atmosphere

2.1: methanol; sodium methylate / methanol / 1 h / 20 °C / Inert atmosphere

3.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 17 h

4.1: guanidine hydrochloride; sodium ethanolate / ethanol / 1.5 h / 96 °C

With 1H-imidazole; methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; guanidine hydrochloride; sodium methylate; sodium ethanolate; In methanol; ethanol; N,N-dimethyl-formamide;