(4R,5S)-3-(isopropylthio)-4-methyl-5-phenyloxazolidin-2-one

Base Information

• Chemical Name: (4R,5S)-3-(isopropylthio)-4-methyl-5-phenyloxazolidin-2-one
• CAS No.: 1427662-36-9
• Molecular Formula: C₁₃H₁₇NO₂S
• Molecular Weight: 251.349
• Mol file: 1427662-36-9.mol

Synonyms:(4R,5S)-3-(isopropylthio)-4-methyl-5-phenyloxazolidin-2-one

Chemical Property of (4R,5S)-3-(isopropylthio)-4-methyl-5-phenyloxazolidin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5S)-3-(isopropylthio)-4-methyl-5-phenyloxazolidin-2-one

There total 1 articles about (4R,5S)-3-(isopropylthio)-4-methyl-5-phenyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-methyl-5-phenyloxazolidin-2-one (77943-39-6) + isopropyl isopropanethiosulfonate (10027-69-7) → (4R,5S)-3-(isopropylthio)-4-methyl-5-phenyloxazolidin-2-one (1427662-36-9)

Guidance literature:

4-methyl-5-phenyloxazolidin-2-one; With n-butyllithium; In tetrahydrofuran; at 0 ℃;

isopropyl isopropanethiosulfonate; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jo302798j

Reference yield:

(4R,5S)-3-(isopropylthio)-4-methyl-5-phenyloxazolidin-2-one (1427662-36-9) → 4-methyl-5-phenyloxazolidin-2-one (77943-39-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetonitrile / 20 °C

2.1: n-butyllithium; isopropylmagnesium chloride / hexane; tetrahydrofuran / -20 - -5 °C

2.2: 0.5 h / -30 °C

With n-butyllithium; isopropylmagnesium chloride; In tetrahydrofuran; hexane; acetonitrile;

DOI:10.1021/jo302798j

Reference yield:

(4R,5S)-3-(isopropylthio)-4-methyl-5-phenyloxazolidin-2-one (1427662-36-9) + chloroamine-T (127-65-1) → C20H24N2O4S2

Guidance literature:

In acetonitrile; at 20 ℃;

DOI:10.1021/jo302798j

upstream raw materials:

4-methyl-5-phenyloxazolidin-2-one

isopropyl isopropanethiosulfonate

Downstream raw materials:

4-methyl-5-phenyloxazolidin-2-one